ArticleFrontiers in medicine2026
The effect of pectin-supplemented enteral nutrition in mechanically ventilated patients receiving gastric feeding: protocol of a multicenter, open-label, randomized controlled trial (the PROMOTE trial).
Article in Frontiers in medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
20 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Introduction: Enteral nutrition (EN) is the preferred route of medical nutrition therapy for critically ill patients. However, enteral feeding intolerance remains a frequent challenge when implementing EN. Pectin, a water-soluble dietary fiber, has been shown to reduce diarrhea and improve feeding tolerance, but existing evidence remains inconsistent. The PROMOTE trial aims to evaluate whether EN supplemented with pectin, compared to usual care, improves EN delivery in critically ill patients. Methods: This is a multicenter, open-label, randomized, parallel-controlled trial, conducted in 10 centers across China. Newly admitted adult critically ill patients who received invasive mechanical ventilation for less than 72 h and had an indication for EN via gastric access will be enrolled. In addition to standard care, patients assigned to the intervention group will receive EN supplemented with 90 g of pectin per 500 mL of EN solution. The study intervention will be discontinued 7 days after randomization, upon discharge from the study site, upon death, or upon cessation of gastric feeding, whichever occurs first. The primary outcome is the ratio of EN energy intake to the prescribed target energy on Day 5 after randomization. Secondary outcomes include daily energy and protein intake, the incidence of enteral feeding intolerance, duration of ICU stay, duration of mechanical ventilation, duration of hospital stay, 28-day mortality, ICU-free, hospital-free and ventilation-free days to 28 days. Discussion: This study investigates whether pectin-supplemented EN enhances gastric feeding tolerance and clinical outcomes in critically ill patients. The finding will provide evidence on pectin's efficacy in optimizing EN delivery and guide early gastric feeding strategies in critical care. Clinical trial registration: https://www.chictr.org.cn, identifier ChiCTR2300078477.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.