Evidence map›Paper›PMID 42415781›Full record

ArticleFrontiers in medicine2026

Renin and 1-year mortality in critically ill patients with ARDS: trajectories, discrimination, and survival analysis.

Gabriele Melegari, Alessandro Belletti, Federica Arturi, Antonio Giansante, Arianna Gaspari, Fabio Gazzotti, Elisabetta Bertellini, Giovanni Landoni, Alberto Barbieri

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Gabriele MelegariSurgical Medical and Dental Department of Morphological Sciences related to Transplant, Oncology and Regenerative Medicine, University Hospital of Modena, Modena, Italy.
Alessandro BellettiDepartment of Anesthesia and Intensive Care, IRCCS San Raffaele Scientific Institute, Milan, Italy.
Federica ArturiSchool of Anaesthesia and Intensive Care, Universita degli Studi di Modena e Reggio Emilia, Modena, Italy.
Antonio GiansanteEsercito Italiano, Rome, Italy.
Arianna GaspariAnaesthesia and Intensive Care, Azienda Ospedaliero-Universitaria di Modena, Modena, Italy.
Fabio GazzottiAnaesthesia and Intensive Care, Azienda Ospedaliero-Universitaria di Modena, Modena, Italy.
Elisabetta BertelliniSchool of Anaesthesia and Intensive Care, Universita degli Studi di Modena e Reggio Emilia, Modena, Italy.
Giovanni LandoniDepartment of Anesthesia and Intensive Care, IRCCS San Raffaele Scientific Institute, Milan, Italy.
Alberto BarbieriSchool of Anaesthesia and Intensive Care, Universita degli Studi di Modena e Reggio Emilia, Modena, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: We investigated whether early and serial plasma renin concentration (PRC) is associated with 1-year mortality in critically ill patients with COVID-19-related acute respiratory distress syndrome (ARDS). Methods: We conducted a single-center retrospective cohort study in a tertiary intensive care unit, including exclusively patients with COVID-19-related ARDS. PRC was measured at 72 h (T0), 120 h (T1), and 168 h (T2) after intensive care unit (ICU) admission. Chronic renin-angiotensin-aldosterone system (RAAS) inhibitors (ACEi/ARB) were discontinued on admission. The primary endpoint was 1-year mortality. Results: The analysis set included 104 mechanically ventilated patients with COVID-19-related ARDS and available 1-year outcome; 48/104 (46%) died within one year. Higher renin was associated with 1-year mortality at T0 (OR 1.94; Conclusion: In patients with severe COVID-19-related ARDS, early renin (72 h) is independently associated with 1-year mortality, and serial trajectories provide additional prognostic information. Prospective multicenter validation is warranted.

Indexed as

biomarkerCOVID-19intensive carelong-term outcomemortalityRAASreninrisk stratification

Identifiers

PMID42415781
PMCPMC13337720

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.