Evidence map›Paper›PMID 42415716›Full record

ArticleJournal of precision medicine (Amsterdam, Netherlands)2025

Precision therapeutic tRNA rescue of nonsense mutation R166X in

Allison Spillane, Enes Akyuz, Meha Kabra, Divya Sinha, Cheryl Soref, Lionel Gissot, Ahmad Al Saneh, Sanjai K Pillala, Pawan K Shahi, Krishanu Saha and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of precision medicine (Amsterdam, Netherlands), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Allison SpillaneUniversity of Wisconsin-Madison, Department of Pediatrics, Wisconsin, USA.
Enes AkyuzUniversity of Wisconsin-Madison, Department of Pediatrics, Wisconsin, USA.
Meha KabraUniversity of Wisconsin-Madison, Department of Pediatrics, Wisconsin, USA.
Divya SinhaUniversity of Wisconsin-Madison, McPherson Eye Research Institute, Wisconsin, USA.
Cheryl SorefUniversity of Wisconsin-Madison, McPherson Eye Research Institute, Wisconsin, USA.
Lionel GissotUniversity of Iowa, Carver College of Medicine, Department of Molecular Physiology and Biophysics, Iowa, USA.
Ahmad Al SanehUniversity of Iowa, Carver College of Medicine, Department of Molecular Physiology and Biophysics, Iowa, USA.
Sanjai K PillalaUniversity of Wisconsin-Madison, Department of Pediatrics, Wisconsin, USA.
Pawan K ShahiUniversity of Wisconsin-Madison, Department of Pediatrics, Wisconsin, USA.
Krishanu SahaUniversity of Wisconsin-Madison, McPherson Eye Research Institute, Wisconsin, USA.
David M GammUniversity of Wisconsin-Madison, McPherson Eye Research Institute, Wisconsin, USA.
Christopher A AhernUniversity of Iowa, Carver College of Medicine, Department of Molecular Physiology and Biophysics, Iowa, USA.
Bikash R PattnaikUniversity of Wisconsin-Madison, Department of Pediatrics, Wisconsin, USA.ORCID 0000-0002-5385-358X

Funding

UW COMPREHENSIVE CANCER CENTER SUPPORTP30CA014520 · NCI · UNIVERSITY OF WISCONSIN-MADISON · PI Justine Yang Bruce · 1985 to 2026
$142.6M
Waisman Center Intellectual and Developmental Disabilities Research CenterP50HD105353 · NICHD · UNIVERSITY OF WISCONSIN-MADISON · PI Qiang Chang · 2021 to 2026
$8.5M
Restoring Vision with High-Fidelity Nonsense Codon CorrectionR24EY032434 · NEI · UNIVERSITY OF WISCONSIN-MADISON · PI AHERN, CHRISTOPHER A, GAMM, DAVID M · 2021 to 2025
$7.8M
NCI NIH HHS P30 CA014520NEI NIH HHS R24 EY032434NICHD NIH HHS P50 HD105353
6 · The paper itself

Abstract

The

Indexed as

Genome editingIon channelKir7.1Nonsense mutationPhysiologyTherapeutic tRNA

Identifiers

PMID42415716
PMCPMC13340877

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.