ArticleThe Canadian journal of urology2026
The effect of Sambucus nigra extract in the treatment of interstitial cystitis.
Article in The Canadian journal of urology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveSambucus nigra (SN) has been found to exhibit strong antioxidant properties and anti-inflammatory effects. In our study, we aimed to investigate the therapeutic effects of Sambucus nigra extracts (SNe) in interstitial cystitis, a condition in which inflammation plays a significant role in its pathophysiology.
methodsThirty Wistar albino adult female rats were used in this study. All rats were housed at an average room temperature of 23°C, with a 12-h light/dark cycle, and had ad libitum access to food. The rats were divided into three groups: Group 1 (n = 10): Control (sham) group, Group 2 (n = 10): Interstitial cystitis group, and Group 3 (n = 10): Treatment group. Rats in Group 3 were administered oral Sambucus nigra extract at a dose of 0.040 g/kg every other day for a total of 8 weeks. Bladder tissues were examined both histologically and immunohistochemically, with a focus on mast cells and the presence of Interleukin-6 (IL-6), Interleukin-8 (IL-8), Vascular Endothelial Growth Factor (VEGF), and Tumor Necrosis Factor-α (TNF-α).
resultsThe findings of chronic inflammation were striking in the bladder sections of the interstitial cystitis group. In the treatment group, regenerating transitional epithelium, a compact appearance in the lamina propria, and a decrease in inflammatory cells and mast cells were observed. While significant improvements were noted in IL-8, TNF-α, and mast cell counts, there was a reduction in IL-6 and VEGF levels, although this reduction was not statistically significant.
conclusionSambucus nigra, significantly reduces TNF-α, Mast cell, VEGF, IL-6, and IL-8 levels in interstitial cystitis (IC) bladder tissue. It provides recovery in damaged bladder epithelium, smooth muscle, and basal membrane. SN attracts attention as an important agent due to its effects in the treatment of IC.
Indexed as
Identifiers
42415588What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.