Evidence map›Paper›PMID 42415492›Full record

ArticleMagnetic resonance in medicine2026

Cartesian MPnRAGE for Efficient Simultaneous Multi-Contrast and Quantitative Relaxometry Imaging.

Carly A Allen, Kevin M Johnson, Bernadette T Gillick, Maren E Schimek, Andrew L Alexander, Steven R Kecskemeti

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Magnetic resonance in medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Carly A AllenDepartment of Medical Physics, The University of Wisconsin-Madison, Madison, Wisconsin, USA.ORCID https://orcid.org/0009-0001-2896-7200
Kevin M JohnsonDepartment of Medical Physics, The University of Wisconsin-Madison, Madison, Wisconsin, USA.ORCID https://orcid.org/0000-0002-8660-0853
Bernadette T GillickDepartment of Pediatrics, The University of Wisconsin-Madison, Madison, Wisconsin, USA.
Maren E SchimekWaisman Center, The University of Wisconsin-Madison, Madison, Wisconsin, USA.
Andrew L AlexanderDepartment of Medical Physics, The University of Wisconsin-Madison, Madison, Wisconsin, USA.
Steven R KecskemetiDepartment of Medical Physics, The University of Wisconsin-Madison, Madison, Wisconsin, USA.ORCID https://orcid.org/0000-0003-3589-430X

Funding

Waisman Center Intellectual and Developmental Disabilities Research CenterP50HD105353 · NICHD · UNIVERSITY OF WISCONSIN-MADISON · PI Brittany Gail Travers · 2021 to 2026
$8.5M
Motion Robust Relaxometry for Infant NeuroimagingR01HD108868 · NICHD · UNIVERSITY OF WISCONSIN-MADISON · PI ALEXANDER, ANDREW L, GILLICK, BERNADETTE THERESE · 2022 to 2025
$2.5M
High Performance Gradient System for Advanced Neuroimaging ResearchS10OD030415 · OD · UNIVERSITY OF WISCONSIN-MADISON · PI ALEXANDER, ANDREW L · 2021 to 2021
$2.0M
Eunice Kennedy Shriver National Institute of Child Health and Human Development P50 HD105353NICHD NIH HHS P50 HD105353NICHD NIH HHS R01 HD108868NIH HHS R01 HD108868NIH HHS S10 OD030415
6 · The paper itself

Abstract

purposeT1-weighted images with different weighting and T1 quantification can be useful in the differentiation of both native and pathologic tissue; however, acquiring multiple images requires substantial time. A rapid and robust brain imaging sequence was developed to simultaneously provide quantitative T1 maps and multiple T1-weighted images.

methodsA novel 3D Cartesian MPnRAGE sequence was developed that collects multiple frames at different inversion times with an interleaved variable density Poisson sampling. Varying flip angles were used to enable B

resultsIn under 5 min, Cartesian MPnRAGE generated 10 high-quality T1-weighted images of different contrasts across the inversion recovery curve, including white matter nulled, gray matter nulled, and cerebral spinal fluid nulled frames. The 10 inversion times at varying flip angles produced accurate T1 values compared to gold standard T1 fitting, and test-retest scans resulted in low variation. In vivo scan results demonstrate the feasibility of Cartesian MPnRAGE acquisition.

conclusionThis work shows the ability of the Cartesian MPnRAGE sequence to provide accurate and efficient whole brain quantitative T1 mapping and multiple image contrasts in a reasonable acquisition time, offering an alternative acquisition strategy to existing approaches.

Indexed as

BrainImage Processing, Computer-AssistedImaging, Three-DimensionalMagnetic Resonance ImagingAdultAlgorithmsFemaleHumansImage Interpretation, Computer-AssistedMalePhantoms, ImagingReproducibility of Resultsdouble inversion recoveryinversion recoveryMPRAGEquantitative imagingrelaxometryT1 mappingT1‐weighted imaging

Identifiers

PMID42415492
PMCPMC13527239

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.