Evidence map›Paper›PMID 42415399›Full record

ReviewComprehensive Physiology2026

The Interstitial Fluid Compartment: Still Unrecognized or Biophysically Well Described?

Daniela Negrini, Giuseppe Miserocchi

Abstract readReview
In one paragraph

Review in Comprehensive Physiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Daniela NegriniDepartment of Medicine and Technological Innovation (DIMIT), University of Insubria, Varese, Italy.
Giuseppe MiserocchiSchool of Medicine and Surgery, University of Milano-Bicocca, Monza, Italy.ORCID https://orcid.org/0000-0002-4474-8059

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The proposal of a "new third bodily system for circulation of fluid" has been recently put forward. The present article sheds light on all available physiological knowledge concerning exactly this same space, defined as "interstitial compartment" as originally hypothesized by Ernest Starling about 130 years ago. We provide here a brief updated summary of the main morpho-functional features and corresponding analysis concerning capillaries microfiltration, interstitial fluid dynamics, and lymphatic drainage.

Indexed as

Extracellular FluidAnimalsCapillariesHumans

Identifiers

PMID42415399
PMCPMC13342484

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.