Evidence map›Paper›PMID 42415372›Full record

ArticleAdvanced materials (Deerfield Beach, Fla.)2026

Mechanism-Driven Nanoformulations for Cognitive Impairment Induced by Intermittent Hypoxia and Periodontitis.

Kai-Run Zhang, Tianbao Zhu, An-Qi Liu, Jia-Jia Deng, Ya-Li Han, Sheng-Cai Qi, Xue Liu, Tian-Yi Jiang, Ming-Rui Zhai, Yu-Ying He and 6 more

Abstract read
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In one paragraph

Article in Advanced materials (Deerfield Beach, Fla.), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Kai-Run ZhangDepartment of Orthodontics, Shanghai Stomatological Hospital & School of Stomatology, Shanghai Key Laboratory of Craniomaxillofacial Development and Diseases, Fudan University, Shanghai, China.
Tianbao ZhuLaboratory of Advanced Materials, Department of Chemistry, Shanghai Key Lab of Molecular Catalysis and Innovative Materials and State Key Laboratory of Molecular Engineering of Polymers, College of Chemistry and Materials, Fudan University, Shanghai, China.
An-Qi LiuDepartment of Orthodontics, Shanghai Ninth People's Hospital, College of Stomatology, Shanghai Jiao Tong University, School of Medicine. National Clinical Research Center For Oral Diseases, Shanghai Key Laboratory of Stomatology & Shanghai Research Institute of Stomatology, Shanghai, China.
Jia-Jia DengDepartment of Orthodontics, Shanghai Stomatological Hospital & School of Stomatology, Shanghai Key Laboratory of Craniomaxillofacial Development and Diseases, Fudan University, Shanghai, China.
Ya-Li HanShanghai Key Laboratory of Craniomaxillofacial Development and Diseases, Shanghai Stomatological Hospital & School of Stomatology, Fudan University, Shanghai, China.
Sheng-Cai QiDepartment of Prothodontics, Shanghai Stomatological Hospital & School of Stomatology, Shanghai Key Laboratory of Craniomaxillofacial Development and Diseases, Fudan University, Shanghai, China.ORCID https://orcid.org/0000-0001-5015-0662
Xue LiuDepartment of Multidisciplinary Consultant Center, Shanghai Key Laboratory of Craniomaxillofacial Development and Diseases, Shanghai Stomatological Hospital & School of Stomatology, Fudan University, Shanghai, China.
Tian-Yi JiangDepartment of Neurobiology, School of Basic Medical Science, Nanjing Medical University, Nanjing, China.
Ming-Rui ZhaiDepartment of Orthodontics, Shanghai Stomatological Hospital & School of Stomatology, Shanghai Key Laboratory of Craniomaxillofacial Development and Diseases, Fudan University, Shanghai, China.
Yu-Ying HeDepartment of Orthodontics, Shanghai Stomatological Hospital & School of Stomatology, Shanghai Key Laboratory of Craniomaxillofacial Development and Diseases, Fudan University, Shanghai, China.
Xiu-Juan LiDepartment of Orthodontics, Shanghai Stomatological Hospital & School of Stomatology, Shanghai Key Laboratory of Craniomaxillofacial Development and Diseases, Fudan University, Shanghai, China.
Hong-Ting DaDepartment of Laboratory, the First Affiliated Hospital of Anhui Medical University, Hefei, China.ORCID https://orcid.org/0009-0004-3325-1815
Rui XuCollege & Hospital of Stomatology, Anhui Medical University, Anhui Province Key Laboratory of Oral Diseases Research, Hefei, China.
Xiaomin LiLaboratory of Advanced Materials, Department of Chemistry, Shanghai Key Lab of Molecular Catalysis and Innovative Materials and State Key Laboratory of Molecular Engineering of Polymers, College of Chemistry and Materials, Fudan University, Shanghai, China.ORCID https://orcid.org/0000-0001-6056-6928
Jun GaoStomatological Institute of Integrated Innovation, Shanghai Stomatological Hospital & School of Stomatology, Fudan University, Shanghai, China.ORCID https://orcid.org/0000-0002-5925-537X
Yue-Hua LiuDepartment of Orthodontics, Shanghai Stomatological Hospital & School of Stomatology, Shanghai Key Laboratory of Craniomaxillofacial Development and Diseases, Fudan University, Shanghai, China.ORCID https://orcid.org/0000-0003-3033-8873

Funding

National Key Clinical Program on Orthodontics GJLCZDZK-2023-01National Key R&D Program of China 2022YFC2705200National Key R&D Program of China 2024YFC3406401National Natural Science Foundation of China 22405051National Natural Science Foundation of China 22475049National Natural Science Foundation of China 22525501National Natural Science Foundation of China 32371053National Natural Science Foundation of China 82571143Ninth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine JYZZ248Science and Technology Commission of Shanghai Municipality 2024ZDSYS02Science and Technology Commission of Shanghai Municipality 25PY2600100Scientific Research Project of Anhui Provincial Department of Education 2025AHGXZK40288Shanghai Pilot Program for Basic Research-Fudan University 22TQ004Shanghai Top Priority Research Center Program 2023ZZ02009
6 · The paper itself

Abstract

Cognitive impairment is a growing global health challenge, yet its multifactorial drivers remain incompletely understood. Intermittent hypoxia (IH) and periodontitis are identified as significant independent risk factors that frequently co-occur. This study investigates the mechanisms through which these conditions accelerate cognitive decline. Here, utilizing a comorbid mouse model, we demonstrate that outer membrane vesicles (OMVs) derived from Porphyromonas gingivalis exacerbate IH-induced mitochondrial oxidative stress and neuroinflammation, leading to neuronal damage and mitochondrial dysfunction in the hippocampus. Specifically, this process is driven by the activation of the HIF-1α/HMGB1/NLRP3 signaling axis. To target this pathology, an asymmetric RVG-Au&mSiO

Indexed as

Cognitive DysfunctionHypoxiaPeriodontitisAnimalsHippocampusHMGB1 ProteinHypoxia-Inducible Factor 1, alpha SubunitMaleMiceMitochondriaNeuronsNLR Family, Pyrin Domain-Containing 3 ProteinOxidative StressPorphyromonas gingivalisHMGB1 ProteinHypoxia-Inducible Factor 1, alpha SubunitNLR Family, Pyrin Domain-Containing 3 Proteincognitive impairmentintermittent hypoxiananoformulationsoxidative stressperiodontitis

Identifiers

PMID42415372
PMCPMC13532445

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.