Evidence map›Paper›PMID 42415283›Full record

ArticleCatheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions2026

Electrocardiographic Changes After Percutaneous Coronary Intervention for Chronic Total Occlusion.

Matthew J Magoon, Primero Ng, Sudhir Thotakura, Nik Stoyanov, Kathleen E Kearney, William L Lombardi, Neal Chatterjee, Nazem Akoum, Patrick M Boyle, Babak Nazer and 1 more

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Article in Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

11 authors.

Matthew J MagoonDepartment of Bioengineering, University of Washington, Seattle, Washington, USA.ORCID https://orcid.org/0000-0002-5947-3772
Primero NgDivision of Cardiology, Department of Medicine, University of Washington, Seattle, Washington, USA.
Sudhir ThotakuraNorth Texas Heart Center, Dallas, Texas, USA.
Nik StoyanovDepartment of Cardiology, Royal Perth Hospital, Perth, Western Australia Royal Perth Hospital, Western Australia, Australia.
Kathleen E KearneyDivision of Cardiology, Department of Medicine, University of Washington, Seattle, Washington, USA.ORCID https://orcid.org/0000-0002-1360-9216
William L LombardiDivision of Cardiology, Department of Medicine, University of Washington, Seattle, Washington, USA.
Neal ChatterjeeDivision of Cardiology, Department of Medicine, University of Washington, Seattle, Washington, USA.
Nazem AkoumDepartment of Bioengineering, University of Washington, Seattle, Washington, USA.ORCID https://orcid.org/0000-0002-2001-6806
Patrick M BoyleDepartment of Bioengineering, University of Washington, Seattle, Washington, USA.ORCID https://orcid.org/0000-0001-9048-1239
Babak NazerDepartment of Bioengineering, University of Washington, Seattle, Washington, USA.
Lorenzo AzzaliniDivision of Cardiology, Department of Medicine, University of Washington, Seattle, Washington, USA.ORCID https://orcid.org/0000-0001-9758-0360

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundIt is unclear if successful percutaneous coronary intervention (PCI) for chronic total occlusion (CTO) can lead to favorable electrophysiologic changes.

aimsThis study seeks to identify whether electrocardiogram (ECG) markers of arrhythmia risk change after successful CTO revascularization.

methodsSignals from all 10-s 12-lead institutional ECGs were compiled from all patients who underwent CTO PCI between 1/1/2019 and 10/1/2023 at a tertiary medical center. Custom code was developed to analyze ECG signal data and report ECG measurements. ECG changes after PCI were compared for patients with and without technical success, and in patients with a failed attempt followed by a successful one.

resultsA total of 1520 CTO PCIs performed in 1233 patients were included, and 89.8% achieved successful revascularization. In the 1452 cases with ECGs available before and < 12 months after CTO PCI, QT dispersion changed by a median [IQR] of 0 [-16 to 14] ms after successful cases and increased by 8 [-12 to 24] ms after unsuccessful cases (p = 0.0456), but no significant differences were observed in any other arrhythmia risk markers. In the 562 cases with ECGs before and 1-12 months after the intervention, no significant differences were observed between patients with successful or unsuccessful CTO PCI. T-wave axis, but not QRS-T angle, showed a different response (p = 0.0307) when a CTO was revascularized during a repeat PCI after an initially unsuccessful attempt, in the subset of 55 applicable patients.

conclusionsSuccessful CTO PCI is not associated with durable changes in ECG features linked to arrhythmia risk.

Indexed as

Arrhythmias, CardiacCoronary OcclusionElectrocardiographyHeart RatePercutaneous Coronary InterventionAction PotentialsAgedChronic DiseaseFemaleHumansMaleMiddle AgedPredictive Value of TestsRetrospective StudiesRisk AssessmentRisk Factorsarrhythmiachronic total occlusionECGpercutaneous coronary intervention

Identifiers

PMID42415283
PMCPMC13532485

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.