ArticleArchives of public health = Archives belges de sante publique2026
Birthweight and cardiometabolic risk factors in offspring: A systematic review and meta-analysis of cohort studies.
Article in Archives of public health = Archives belges de sante publique, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe association between birthweight and cardiometabolic risk factors in offspring remains incompletely elucidated. Clarifying this relationship is crucial for understanding the origins of developmental disorders and identifying early risk factors. This systematic review and meta-analysis aimed to assess the association of birthweight with anthropometric nutritional status and blood pressure in offspring, and secondarily to evaluate its association with lipid and glucose metabolism.
methodsPubMed, Embase, Cochrane Library, and Web of Science were searched from inception to September 30, 2025. Data were extracted using a standardized form, which included the title, first author, publication year, country, baseline characteristics of participants, exposure variables, grouping method, and outcome measures. The quality of the included studies was assessed using the Newcastle-Ottawa Scale(NOS). Primary endpoints (obesity, overweight, and blood pressure) were pooled and reported as odds ratios (OR) with 95% confidence intervals. A fixed-effects model was used when between-study heterogeneity was low (I²<50%); otherwise, a DerSimonian-Laird random-effects model was used.
resultsA total of 33 cohort studies involving 8,241,597 children were included. High birthweight (≥ 4,000 g) was associated with a higher odds of obesity (OR = 1.62, 95% CI: 1.33-1.95; I²=96.9%) and overweight (OR = 1.51, 95% CI: 1.22-1.86; I²=77.5%). Conversely, low BW (< 2,500 g) was associated with a lower odds of obesity (OR = 0.76, 95% CI: 0.71-0.81; I²=0.0%) and overweight (OR = 0.79, 95% CI: 0.71-0.89; I²=0.0%). Birthweight was negatively associated with systolic blood pressure (SBP) (OR = 0.63, 95% CI: 0.42-0.94; I²=4.2%), although no association was observed between birthweight and diastolic blood pressure (DBP).
conclusionHigh birthweight was associated with a higher likelihood of developing obesity and overweight during childhood and adolescence, while birthweight was negatively correlated with SBP.
trial registrationCRD42024565031.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.