Evidence map›Paper›PMID 42415118›Full record

ArticleGenome biology2026

Defined bacterial consortium highlights the impact of intestinal bacteria on DNA methylation and tumorigenesis.

Claudia Mercado-Rodriguez, Siddhi Chitre, Pyoung Hwa Park, Ye Yang, Anthony Pompetti, Raad Z Gharaibeh, Jason O Brant, Jean-Pierre J Issa, Christian Jobin

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Genome biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Claudia Mercado-Rodriguez *Department of Medicine, University of Florida College of Medicine, Gainesville, FL, USA.ORCID http://orcid.org/0009-0005-9148-9159
Siddhi Chitre *Department of Medicine, University of Florida College of Medicine, Gainesville, FL, USA.ORCID http://orcid.org/0000-0003-2139-3125
Pyoung Hwa ParkCoriell Institute for Medical Research, Camden, NJ, USA.ORCID http://orcid.org/0000-0002-5850-6181
Ye YangDepartment of Medicine, University of Florida College of Medicine, Gainesville, FL, USA.ORCID http://orcid.org/0000-0002-7576-3067
Anthony PompettiCoriell Institute for Medical Research, Camden, NJ, USA.ORCID http://orcid.org/0009-0000-4861-2039
Raad Z GharaibehDepartment of Medicine, University of Florida College of Medicine, Gainesville, FL, USA.ORCID http://orcid.org/0000-0001-5484-8902
Jason O BrantDepartment of Biostatistics, College of Public Health and Health Professions, University of Florida, Gainesville, FL, USA.ORCID http://orcid.org/0000-0002-9800-9251
Jean-Pierre J IssaCoriell Institute for Medical Research, Camden, NJ, USA. jpissa@coriell.org.ORCID http://orcid.org/0000-0003-2258-5030
Christian JobinDepartment of Medicine, University of Florida College of Medicine, Gainesville, FL, USA. Christian.Jobin@medicine.ufl.edu.ORCID https://orcid.org/0000-0002-3733-1001

Funding

NIH HHS NCI R01CA214005
6 · The paper itself

Abstract

backgroundColorectal cancer (CRC) is the second leading cause of cancer-related mortality in the United States. While the gut microbiota has been shown to influence CRC development, the specific contribution of bacteria to DNA methylation and carcinogenesis remains underexplored.

resultsWe colonize two groups of GF Apc

conclusionsThese findings demonstrate that intestinal bacteria with distinct pks activities differentially modulate DNA methylation thereby influencing gene expression and tumor development. This highlights bacterial modulation of epigenetic responses as a potential mechanism underlying CRC progression.

Indexed as

CarcinogenesisColorectal NeoplasmsDNA MethylationGastrointestinal MicrobiomeAnimalsCell ProliferationColitisDNA DamageEscherichia coliMiceMice, Inbred C57BLPromoter Regions, GeneticColibactinEpigeneticsGenotoxicityGerm-free miceMicrobiomeNeoplasia

Identifiers

PMID42415118
PMCPMC13343937

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.