Evidence map›Paper›PMID 42414937›Full record

Trial reportBMC infectious diseases2026

A sticker reminder intervention to promote intravenous-to-oral fluoroquinolone conversion: a cluster-randomized controlled trial.

Jakaphan Sakchainan, Sumunthana Tunprayoon, Surangkana Samanloh, Pinyo Rattanaumpawan

Registry-linked trialAbstract readRandomized Controlled Trial
In one paragraph

Trial report in BMC infectious diseases, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07361185 (A Sticker Reminder Intervention to Promote Intravenous-to-Oral Fluoroquinolone Switching), which is not on this map. Not yet cited in PubMed.

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0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07361185 naterminatednot on this map

A Sticker Reminder Intervention to Promote Intravenous-to-Oral Fluoroquinolone Switching: A Cluster-Randomized Controlled Trial

TypeinterventionalSponsorMahidol UniversityRan2020 to 2024Enrolled168ConditionsFluoroquinolone, AdultArmsSticker reminder
3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Jakaphan Sakchainan *Department of Medicine, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, 10700, Thailand.
Sumunthana Tunprayoon *Pharmacy Department, Siriraj Hospital, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, 10700, Thailand.
Surangkana SamanlohClinical Trials Unit, Research Department, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, 10700, Thailand.
Pinyo RattanaumpawanDepartment of Medicine, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, 10700, Thailand. pinyo.rat@mahidol.ac.th.ORCID https://orcid.org/0000-0002-2964-6732

Funding

Faculty of Medicine Siriraj Hospital, Mahidol University R016331061Health Systems Research Institute 67-012
6 · The paper itself

Abstract

objectiveTo evaluate the effectiveness of a simple sticker reminder in increasing intravenous-to-oral (IV-to-PO) fluoroquinolone (FQ) conversion rates.

designSingle-center, cluster-randomized controlled trial.

settingForty-five general wards at Siriraj Hospital, Bangkok, Thailand, from July 2020 through December 2024. PATIENTS: Hospitalized adult patients receiving intravenous fluoroquinolones who met predefined IV-to-PO conversion criteria.

methodsWards were randomized 1:1 to either a sticker reminder intervention or standard care. In the intervention group, a reminder sticker was placed on the vital signs sheet of eligible patients. The primary outcome was the proportion of IV-to-PO conversion in the intention-to-treat (ITT) and modified intention-to-treat (mITT) populations.

resultsA total of 168 patients were enrolled (85 intervention, 83 control). In the ITT population, the IV-to-PO conversion rate was 58.8% in the intervention group versus 42.2% in the control group (p-value = 0.03). In the mITT population (patients meeting all conversion criteria), the intervention group had a significantly higher conversion rate (69.0% vs. 48.5%; p-value = 0.01). No significant differences were observed in clinical cure rates, in-hospital mortality, length of stay, duration of either IV FQ or PO FQ therapy.

conclusionA sticker reminder intervention effectively increases IV-to-PO FQ conversion among eligible patients without compromising clinical safety. Future large-scale and qualitative studies are needed to further validate these benefits and explore prescriber hesitation.

trial registrationClinicalTrials.gov NCT07361185 (retrospectively registered on 22 January 2026).

Indexed as

Anti-Bacterial AgentsFluoroquinolonesReminder SystemsAdherence InterventionsAdministration, IntravenousAdministration, OralAgedFemaleHumansMaleMiddle AgedThailandAnti-Bacterial AgentsFluoroquinolonesAntibioticAntimicrobial stewardshipFluoroquinolone

Identifiers

PMID42414937
PMCPMC13628710

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.