Evidence map›Paper›PMID 42414886›Full record

ArticleJournal of neurodevelopmental disorders2026

Processing of emotional faces has unique functional and cytoarchitectural associations in those with an autism spectrum diagnosis.

Zachary P Christensen, Edward G Freedman, John J Foxe

Abstract read
In one paragraph

Article in Journal of neurodevelopmental disorders, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

3 authors.

Zachary P ChristensenThe Frederick J. and Marion A. Schindler Cognitive Neurophysiology Laboratory, The Del Monte Institute for Neuroscience Department of Neuroscience, School of Medicine and Dentistry, University of Rochester, Rochester, NY, 14642, USA.
Edward G Freedman *The Frederick J. and Marion A. Schindler Cognitive Neurophysiology Laboratory, The Del Monte Institute for Neuroscience Department of Neuroscience, School of Medicine and Dentistry, University of Rochester, Rochester, NY, 14642, USA. ed_freedman@urmc.rochester.edu.
John J Foxe *The Frederick J. and Marion A. Schindler Cognitive Neurophysiology Laboratory, The Del Monte Institute for Neuroscience Department of Neuroscience, School of Medicine and Dentistry, University of Rochester, Rochester, NY, 14642, USA. john_foxe@urmc.rochester.edu.ORCID https://orcid.org/0000-0002-4300-3098

Funding

University of Rochester Intellectual and Developmental Disabilities Research CenterP50HD103536 · NICHD · UNIVERSITY OF ROCHESTER · PI JOHN J FOXE, Anna K Majewska · 2020 to 2026
$9.8M
NRSA Training CoreTL1TR002000 · NCATS · UNIVERSITY OF ROCHESTER · PI THAKAR, JUILEE, VAN WIJNGAARDEN, EDWIN · 2016 to 2024
$4.1M
Eunice Kennedy Shriver National Institute of Child Health and Human Development HD103536NCATS NIH HHS TL1 TR002000NCATS NIH HHS TR002000NICHD NIH HHS P50 HD103536
6 · The paper itself

Abstract

Those with an autism spectrum diagnosis (ASD) have been found to process emotional faces differently than other populations. Processing of emotional faces requires engagement of temporal, frontal, occipital, and limbic brain regions. Functional activity has been shown to differ in those with an ASD, particularly in the amygdala, inferior frontal cortex (IFC), and temporal brain regions. However, the consistency and direction of these associations have been inconsistent across studies. Recent findings have demonstrated that measures of neuron density differ in those with an ASD. Some of these regional differences in cytoarchitecture coincide with regions important to emotional facial processing. Therefore, the interaction between cytoarchitecture and functional activity may be important in elucidating unique neurophysiology in ASD. The present study uses diffusion weighted imaging (DWI) and functional magnetic resonance imaging (fMRI) data from the Adolescent Brain Cognitive Development

Indexed as

Autism Spectrum DisorderBrainEmotionsFacial ExpressionFacial RecognitionAdolescentAmygdalaBrain MappingChildDiffusion Magnetic Resonance ImagingFemaleHumansMagnetic Resonance ImagingMaleYoung Adult

Identifiers

PMID42414886
PMCPMC13628806

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.