Evidence map›Paper›PMID 42414764›Full record

ArticleInflammopharmacology2026

Cytotoxic and computational profiling of 2-mercaptobenzimidazole Mannich derivatives: structure activity relationship and carbonic anhydrase binding assessment.

Muhammad Naeem, Arooj Mohsin Alvi, Muhammad Mehmmod Moin Ul Haq, Najia Shabbir, Shumaila Mehdi, Areen Khalid, Saqib Khan, Hafiz Muhammad Ahmad, Najm Ul Hassan Khan, Muhammad Nouman Arif and 1 more

Abstract read
PubMed Publisher
In one paragraph

Article in Inflammopharmacology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Muhammad NaeemPak-Austria Fachhochschule, Institute of Applied Sciences and Technology, Khanpur Road, Mang Haripur, Khyber Pakhtunkhwa, Pakistan.
Arooj Mohsin AlviFaculty of Pharmacy, IBADAT International University, Islamabad, Pakistan.
Muhammad Mehmmod Moin Ul HaqFaculty of Pharmacy, Capital University of Science & Technology, Islamabad, Pakistan.
Najia ShabbirDepartment of Pharmacy, Iqra University H-9 Campus, Islamabad, Pakistan.
Shumaila MehdiDepartment of Pharmacology, Faculty of Pharmaceutical Sciences, Government College University, Faisalabad, Pakistan.
Areen KhalidFaculty of Pharmacy, Capital University of Science & Technology, Islamabad, Pakistan.
Saqib KhanDepartment of Pharmacy, University of Swabi, Swabi, Khyber Pakhtunkhwa, Pakistan.
Hafiz Muhammad AhmadDepartment of Pharmacy, Faculty of Health & Pharmaceutical Sciences, University of Agriculture, Faisalabad, Pakistan.
Najm Ul Hassan KhanMargalla Institute of Health Sciences, Rawalpindi, Pakistan.
Muhammad Nouman ArifDepartment of Pharmacy, Iqra University H-9 Campus, Islamabad, Pakistan.
Hafiz Aamir Ali KharlNarcotics Forensic Laboratory, Anti-Narcotics Force, Ministry of Interior & Narcotics Control, Islamabad, Pakistan. aamirkharl43@gmail.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Carbonic anhydrases (CAs) are zinc-dependent metalloenzymes that regulate pH homeostasis and are overexpressed in several hypoxic tumors. This study integrates experimental cytotoxicity screening with molecular docking and ADME profiling to evaluate 2-mercaptobenzimidazole Mannich derivatives (AK1 and AK12). Cytotoxicity was evaluated using brine shrimp lethality (LC

Indexed as

BenzimidazolesCarbonic Anhydrase InhibitorsCarbonic AnhydrasesAnimalsArtemiaCarbonic Anhydrase IICell SurvivalHumansMannich BasesMolecular Docking SimulationStructure-Activity Relationship2-mercaptobenzimidazoleBenzimidazolesCarbonic Anhydrase IICarbonic Anhydrase InhibitorsCarbonic AnhydrasesMannich Bases2-mercaptobenzimidazoleADMECarbonic anhydraseCytotoxicityDockingGood health & wellbeingMannich bases

Identifiers

PMID42414764

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.