Evidence map›Paper›PMID 42414693›Full record

ReviewNaunyn-Schmiedeberg's archives of pharmacology2026

Rudolf Buchheim Award 2026: Regulation of thyroid hormone gatekeepers by thyrotropin in tanycytes.

Akila Chandrasekar

Abstract readHistorical ArticleReview
PubMed Publisher
In one paragraph

Review in Naunyn-Schmiedeberg's archives of pharmacology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author.

Akila ChandrasekarInstitute for Experimental and Clinical Pharmacology and Toxicology, University of Lübeck, Lübeck, Germany. akila.chandrasekar@uni-luebeck.de.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The Rudolf Buchheim Award is an annual prize awarded by the German Society for Experimental and Clinical Pharmacology and Toxicology (DGPT) to recognize outstanding work from young researchers in the fields of pharmacology and toxicology. One of the 2026 Rudolf Buchheim Award recipients, Akila Chandrasekar, investigated how hypothalamic tanycytes regulate local thyroid hormone (TH) availability through TH transporters and deiodinases in the lab of Prof. Dr. Markus Schwaninger under the guidance of PD Dr. Helge Müller-Fielitz at the University of Lübeck. Her research highlights the role of TSH, from the pars distalis, in inducing the expression of TH-gatekeeper genes Slco1c1, Dio2, and Dio3 in primary tanycytes and ex vivo hypothalamic slices. Using pharmacological approaches, she identified two parallel signaling pathways: a Gα

Indexed as

Awards and PrizesEpendymoglial CellsThyroid HormonesThyrotropinAnimalsHistory, 21st CenturyHumansSignal TransductionThyroid HormonesThyrotropinDeiodinasePKAPKCTanycytesThyroid hormonesTSH receptor

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.