Evidence map›Paper›PMID 42414585›Full record

ArticleThe EMBO journal2026

PP2A phosphatase regulates Hippo signalling in dual manner.

Aashika Sekar, Alberto Rizzo, Elodie Sins, Alexander D Fulford, Lucy Silcock, Paulo S Ribeiro

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The EMBO journal, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Aashika SekarCentre for Tumour Biology, Barts Cancer Institute, Queen Mary University of London, Charterhouse Square, London, UK. aashika.sekar@crick.ac.uk.ORCID http://orcid.org/0000-0003-0274-6984
Alberto RizzoCentre for Tumour Biology, Barts Cancer Institute, Queen Mary University of London, Charterhouse Square, London, UK.
Elodie SinsCentre for Tumour Biology, Barts Cancer Institute, Queen Mary University of London, Charterhouse Square, London, UK.
Alexander D FulfordCentre for Tumour Biology, Barts Cancer Institute, Queen Mary University of London, Charterhouse Square, London, UK.
Lucy SilcockCentre for Tumour Biology, Barts Cancer Institute, Queen Mary University of London, Charterhouse Square, London, UK.
Paulo S RibeiroCentre for Tumour Biology, Barts Cancer Institute, Queen Mary University of London, Charterhouse Square, London, UK. p.baptista-ribeiro@qmul.ac.uk.ORCID http://orcid.org/0000-0002-6020-6321

Funding

Resource Component: Acquisition, maintenance and distribution of Drosophila stocksP40OD018537 · OD · TRUSTEES OF INDIANA UNIVERSITY · PI Annette L. Parks · 2014 to 2026
$13.5M
Academy of Medical Sciences (The Academy of Medical Sciences) SBF001/1018Barts Charity G-002761Brain Tumour Charity (The Brain Tumour Charity) GN-000408Cancer Research UK (CRUK) C16420/A18066Cancer Research UK (CRUK) CTRQQR-2021/100004Cancer Research UK (CRUK) S_3967NIH HHS P40 OD018537UKRI | Biotechnology and Biological Sciences Research Council (AFRC) BB/T004576/1Wellcome Trust
6 · The paper itself

Abstract

Hippo signalling is an evolutionarily conserved pathway that regulates tissue growth. The FERM domain protein Expanded (Ex) integrates polarity cues to activate the Hippo pathway. Previous work has shown that the apicobasal polarity protein Crumbs can limit Hippo activity by promoting the phosphorylation and degradation of Ex. Here, we provide evidence that serine/threonine phosphatase, protein phosphatase 2A (PP2A) has a dual role in the regulation of Hippo signalling in Drosophila cell culture and wing discs. We show that PP2A

Indexed as

Drosophila melanogasterDrosophila ProteinsIntracellular Signaling Peptides and ProteinsProtein Phosphatase 2Protein Serine-Threonine KinasesSignal TransductionAnimalsDrosophilaHippo KinasesMembrane ProteinsPhosphorylationTumor Suppressor ProteinsWings, AnimalDrosophila Proteinsex protein, DrosophilaHippo Kinaseshpo protein, DrosophilaIntracellular Signaling Peptides and Proteinskibra protein, DrosophilaMembrane ProteinsProtein Phosphatase 2Protein Serine-Threonine KinasesTumor Suppressor Proteins

Identifiers

PMID42414585
PMCPMC13482807

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.