Evidence map›Paper›PMID 42414564›Full record

ArticleNeuropsychopharmacology : official publication of the American College of Neuropsychopharmacology2026

Pharmacokinetics and concentration-behavioral effect relationships differ between brain subcompartments.

Kevin M Honeywell, Julian Gerson, Murat K Erdal, Matthew H McDonough, Marlaina R Stocco, Kaylyn K Leung, Nicole A Emmons, Jenny M Gibson, Kirstin N Bui, Wendy Meiring and 3 more

Abstract read
PubMed Publisher
In one paragraph

Article in Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Kevin M HoneywellPsychological and Brain Sciences, University of California, Santa Barbara, CA, USA.ORCID http://orcid.org/0000-0001-7127-5712
Julian GersonPsychological and Brain Sciences, University of California, Santa Barbara, CA, USA.ORCID http://orcid.org/0000-0002-5922-4477
Murat K ErdalElectrical and Computer Engineering, University of California, Santa Barbara, CA, USA.ORCID http://orcid.org/0000-0002-6073-2380
Matthew H McDonoughStatistics and Applied Probability, University of California, Santa Barbara, CA, USA.
Marlaina R StoccoPsychological and Brain Sciences, University of California, Santa Barbara, CA, USA.
Kaylyn K LeungChemistry and Biochemistry, University of California, Santa Barbara, CA, USA.
Nicole A EmmonsPsychological and Brain Sciences, University of California, Santa Barbara, CA, USA.
Jenny M GibsonInterdepartmental Program in Quantitative Biology, University of California, Santa Barbara, CA, USA.
Kirstin N BuiPsychological and Brain Sciences, University of California, Santa Barbara, CA, USA.
Wendy MeiringStatistics and Applied Probability, University of California, Santa Barbara, CA, USA.
João P HespanhaElectrical and Computer Engineering, University of California, Santa Barbara, CA, USA.
Kevin W PlaxcoChemistry and Biochemistry, University of California, Santa Barbara, CA, USA.
Tod E KippinPsychological and Brain Sciences, University of California, Santa Barbara, CA, USA. kippin@ucsb.edu.

Funding

U.S. Department of Health & Human Services | NIH | National Institute on Drug Abuse (NIDA) R01DA51100U.S. Department of Health & Human Services | NIH | National Institute on Drug Abuse (NIDA) R01ED022015
6 · The paper itself

Abstract

Little is known regarding the extent to which the barriers separating brain subcompartments lead to differential drug transport into these subcompartments and whether such differences impact the behavioral effects of drugs. Against this background, here we have adopted electrochemical aptamer-based (EAB) sensors, a seconds-resolved, in vivo molecular measurement tool, to two tasks. First, we have measured the pharmacokinetics associated with the anesthetic procaine crossing the blood-brain-barrier into the solid tissue of the hippocampus and crossing the blood-cerebrospinal fluid barrier into the lateral ventricle. Second, we have determined the extent to which procaine concentrations in these two subcompartments correlate with the behavioral response the drug elicits. Performing these studies, we find that, whereas the drug's elimination kinetics are effectively indistinguishable between the two subcompartments, penetration into the hippocampus is statistically significantly slower than into the lateral ventricle. The relationships between drug concentration and the resulting behavioral effect also differ significantly between the two subcompartments, with the correlation between concentration and drug-induced suppression of ambulatory behavior being stronger in the hippocampus than in the lateral ventricle. This difference presumably arises because hippocampal concentrations more accurately reflect procaine exposure at the drug's site of action.

Identifiers

PMID42414564

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.