Low PEEP ventilation in TGF-β1 induced lung injury triggers a reversible lung mechanical deterioration without promoting persistent structural damage.

Franziska Roeder, Lara-Kristin Steinmetz, Martin Kolb, Ulrich A Maus, Bradford J Smith, Lars Knudsen

Abstract read

In one paragraph

Article in Scientific reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Franziska RoederInstitute of Functional and Applied Anatomy, Hannover Medical School, Hannover, Germany.

Lara-Kristin SteinmetzDepartment of Experimental Pneumology, Hannover Medical School, Hannover, Germany.

Martin KolbFirestone Institute for Respiratory Health, Department of Medicine, McMaster University, Hamilton, ON, Canada.

Ulrich A MausDepartment of Experimental Pneumology, Hannover Medical School, Hannover, Germany.

Bradford J SmithDepartment of Biomedical Engineering, College of Engineering Design and Computing, University of Colorado Denver | Anschutz, Aurora, CO, USA.

Lars KnudsenInstitute of Functional and Applied Anatomy, Hannover Medical School, Hannover, Germany. knudsen.lars@mh-hannover.de.ORCID 0000-0002-7926-3879

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

TGF-β1-induced lung injury initially results in surfactant dysfunction and alveolar instability (microatelectases). Morphology showed that at end-expiratory pressure of 2cmH

Indexed as

LungLung InjuryPositive-Pressure RespirationTransforming Growth Factor beta1Ventilator-Induced Lung InjuryAnimalsDisease Models, AnimalMaleMiceMice, Inbred C57BLTransforming Growth Factor beta1Acute respiratory distress syndromeAtelectasisRecruitmentTGF-β1Ventilation induced lung injury

Identifiers

PMID42414447

DOI10.1038/s41598-026-61155-9

PMCPMC13342613

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.