Evidence map›Paper›PMID 42414303›Full record

ArticleNature communications2026

Primary sclerosing cholangitis displays distinct colonic mucosa topography yet a shared mast cell state with ulcerative colitis.

Jacqueline LE Tearle, Ekaterina Sviriaeva, Fan Zhang, Katherine Jl Jackson, Joshua Kaye, Paris Tavakoli, Sabrina Koentgen, Joanna Warren, Raymond R Liang, Pratibha Malhotra and 12 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors.

Jacqueline LE TearleTranslational Genomics Program, Garvan Institute of Medical Research, Darlinghurst, Sydney, NSW, Australia.
Ekaterina SviriaevaTranslational Genomics Program, Garvan Institute of Medical Research, Darlinghurst, Sydney, NSW, Australia.
Fan ZhangMicrobiome Research Centre, St George and Sutherland Campuses, School of Clinical Medicine, University of New South Wales, Sydney, NSW, Australia.
Katherine Jl JacksonImmune Biotherapies Program, Garvan Institute of Medical Research, Darlinghurst, Sydney, NSW, Australia.ORCID http://orcid.org/0000-0002-9952-7069
Joshua KayeTranslational Genomics Program, Garvan Institute of Medical Research, Darlinghurst, Sydney, NSW, Australia.
Paris TavakoliMicrobiome Research Centre, St George and Sutherland Campuses, School of Clinical Medicine, University of New South Wales, Sydney, NSW, Australia.ORCID http://orcid.org/0000-0003-4558-9122
Sabrina KoentgenMicrobiome Research Centre, St George and Sutherland Campuses, School of Clinical Medicine, University of New South Wales, Sydney, NSW, Australia.
Joanna WarrenCellular Genomics Platform, Garvan Institute of Medical Research, Darlinghurst, Sydney, NSW, Australia.
Raymond R LiangTranslational Genomics Program, Garvan Institute of Medical Research, Darlinghurst, Sydney, NSW, Australia.
Pratibha MalhotraTranslational Genomics Program, Garvan Institute of Medical Research, Darlinghurst, Sydney, NSW, Australia.
Cameron WilliamsDepartment of Microbiology and Immunology, The Peter Doherty Institute for Infection and Immunity, Parkville, Melbourne, VIC, Australia.
Ashraful HaqueDepartment of Microbiology and Immunology, The Peter Doherty Institute for Infection and Immunity, Parkville, Melbourne, VIC, Australia.ORCID http://orcid.org/0000-0003-2260-0026
Arteen ArzivianSt. Vincent's Clinical School, University of New South Wales, Sydney, NSW, Australia.
Kavitha K SudhakarTranslational Genomics Program, Garvan Institute of Medical Research, Darlinghurst, Sydney, NSW, Australia.
Drew NeavinTranslational Genomics Program, Garvan Institute of Medical Research, Darlinghurst, Sydney, NSW, Australia.ORCID http://orcid.org/0000-0002-1783-6491
Nicodemus TedlaSchool of Biomedical Sciences, University of New South Wales, Sydney, NSW, Australia.
Andrew KimSt. Vincent's Clinical School, University of New South Wales, Sydney, NSW, Australia.
Craig HaiferDepartment of Gastroenterology and Hepatology, St. Vincent's Hospital Sydney, Darlinghurst, Sydney, NSW, Australia.
Hamish W KingUniversity of Melbourne, Parkville, Melbourne, VIC, Australia.ORCID http://orcid.org/0000-0001-5972-8926
Georgina L HoldMicrobiome Research Centre, St George and Sutherland Campuses, School of Clinical Medicine, University of New South Wales, Sydney, NSW, Australia.
Simon GhalySt. Vincent's Clinical School, University of New South Wales, Sydney, NSW, Australia.
Kylie R JamesTranslational Genomics Program, Garvan Institute of Medical Research, Darlinghurst, Sydney, NSW, Australia. k.james@garvan.org.au.ORCID http://orcid.org/0000-0002-7107-0650

Funding

Department of Health | National Health and Medical Research Council (NHMRC) APP1194063
6 · The paper itself

Abstract

Primary sclerosing cholangitis (PSC) is a chronic, progressing cholestatic disease that often co-occurs with inflammatory bowel disease (PSC-IBD). PSC-IBD affecting the colon (PSC-ulcerative colitis or PSC-UC) resembles clinical UC, but is characterised by less severe disease flares, right-colon predominance, and a greater lifetime risk of colorectal cancer than UC alone. To elucidate differences in the underlying biology between PSC-UC and UC, here we combine single-cell mRNA and antigen receptor sequencing, 16S ribosomal RNA gene analysis and spatial transcriptomics on biopsies from four colon regions of patients with PSC-UC and UC during endoscopic remission or at the time of relapse. We show that the PSC-UC colon, compared to healthy control (HC) or UC colon, harbours distinct and region-specific mucosal-adherent microbial communities and an enrichment of activated CD8 T and γδ T cells at the right colon, even in the absence of histological inflammation. By contrast, a TMEM176B

Indexed as

Cholangitis, SclerosingColitis, UlcerativeColonIntestinal MucosaMast CellsAdultCD8-Positive T-LymphocytesFemaleHumansMaleMembrane ProteinsMiddle AgedReceptors, Antigen, T-Cell, gamma-deltaRNA, Ribosomal, 16SMembrane ProteinsReceptors, Antigen, T-Cell, gamma-deltaRNA, Ribosomal, 16S

Identifiers

PMID42414303
PMCPMC13597510

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.