Evidence map›Paper›PMID 42414141›Full record

ReviewTrends in genetics : TIG2026

Coordinated pre-mRNA processing at the single-transcript level.

Leena P Sen, Karla M Neugebauer

Abstract readReview
In one paragraph

Review in Trends in genetics : TIG, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Leena P SenDepartment of Molecular Biophysics and Biochemistry, Yale University, New Haven, CT, USA.
Karla M NeugebauerDepartment of Molecular Biophysics and Biochemistry, Yale University, New Haven, CT, USA. Electronic address: karla.neugebauer@yale.edu.

Funding

Cross-regulation between transcription and pre-mRNA splicingR01GM112766 · NIGMS · YALE UNIVERSITY · PI Karla M Neugebauer · 2015 to 2026
$5.3M
Predoctoral Program in BiophysicsT32GM149438 · NIGMS · YALE UNIVERSITY · PI Yong Xiong, Elsa Chui Ying Yan · 2023 to 2026
$2.6M
Altered RNA fates due to an MDS driver mutation in SF3B1R01HL167071 · NHLBI · YALE UNIVERSITY · PI Karla M Neugebauer, Manoj M. Pillai · 2024 to 2026
$1.8M
Biogenesis and function of a novel class of stress-induced long non-coding RNAsR01GM140735 · NIGMS · YALE UNIVERSITY · PI NEUGEBAUER, KARLA M, STEITZ, JOAN A. · 2021 to 2024
$1.7M
NHLBI NIH HHS R01 HL167071NIGMS NIH HHS R01 GM112766NIGMS NIH HHS R01 GM140735NIGMS NIH HHS T32 GM149438
6 · The paper itself

Abstract

Pre-mRNA undergoes extensive processing during transcription by RNA polymerase II, including splicing, folding, and 3'-end cleavage and polyadenylation. In this forum, we discuss recent studies that have devised powerful sequencing methods to detect coordination of RNA processing at the level of individual nascent transcripts.

Indexed as

RNA, MessengerRNA PrecursorsRNA Processing, Post-TranscriptionalTranscription, GeneticAnimalsHumansPolyadenylationRNA Polymerase IIRNA SplicingRNA, MessengerRNA Polymerase IIRNA PrecursorspolyadenylationRNA chimerasplicingtranscriptional readthrough

Identifiers

PMID42414141
PMCPMC13459127

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.