Evidence map›Paper›PMID 42414004›Full record

ArticleJournal of clinical periodontology2026

Horizontal Ridge Augmentation Using an rhBMP-2 Loaded Volume-Stable Collagen Matrix Compared to Guided Bone Regeneration: A Preclinical In Vivo Study.

Jin-Young Park, Gi-Seo Song, Seung-Hyun Park, Lorenzo Tavelli, David T Wu, Daniel S Thoma, Ronald E Jung, Ui-Won Jung, Jae-Kook Cha

Abstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of clinical periodontology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Jin-Young ParkDepartment of Periodontology, Research Institute for Periodontal Regeneration, Yonsei University College of Dentistry, Seoul, South Korea.ORCID https://orcid.org/0000-0002-6408-1618
Gi-Seo SongDepartment of Periodontology, Research Institute for Periodontal Regeneration, Yonsei University College of Dentistry, Seoul, South Korea.
Seung-Hyun ParkDepartment of Periodontology, Research Institute for Periodontal Regeneration, Yonsei University College of Dentistry, Seoul, South Korea.ORCID https://orcid.org/0000-0002-6207-8036
Lorenzo TavelliDepartment of Oral Medicine, Infection, and Immunity, Harvard School of Dental Medicine, Boston, Massachusetts, USA.ORCID https://orcid.org/0000-0003-4864-3964
David T WuDepartment of Oral Medicine, Infection, and Immunity, Harvard School of Dental Medicine, Boston, Massachusetts, USA.ORCID https://orcid.org/0000-0002-9752-5377
Daniel S ThomaDepartment of Periodontology, Research Institute for Periodontal Regeneration, Yonsei University College of Dentistry, Seoul, South Korea.ORCID https://orcid.org/0000-0002-1764-7447
Ronald E JungClinic of Reconstructive Dentistry, Center of Dental Medicine, University of Zurich, Zurich, Switzerland.
Ui-Won JungDepartment of Periodontology, Research Institute for Periodontal Regeneration, Yonsei University College of Dentistry, Seoul, South Korea.ORCID https://orcid.org/0000-0001-6371-4172
Jae-Kook ChaDepartment of Periodontology, Research Institute for Periodontal Regeneration, Yonsei University College of Dentistry, Seoul, South Korea.ORCID https://orcid.org/0000-0002-6906-7209

Funding

Ministry of Health & Welfare, Republic of Korea HI22C1609National Research Foundation of Korea RS-2025-00522998
6 · The paper itself

Abstract

aimTo investigate whether incorporation of recombinant human bone morphogenetic protein-2 (rhBMP-2) into a volume-stable collagen matrix (VCMX) enhances horizontal ridge augmentation compared with VCMX alone or guided bone regeneration (GBR).

methodsChronic horizontal ridge defects were created in five canines. Sites randomly received: (1) control, (2) VCMX, (3) VCMX with rhBMP-2 or (4) GBR (deproteinised bovine bone mineral with a collagen membrane). After 8 weeks, outcomes were assessed by profilometry, micro-computed tomography and histomorphometry.

resultsVCMX/rhBMP-2 showed significantly greater new bone volume (181.50 ± 142.32 mm

conclusionsRhBMP-2 delivered via VCMX enhanced horizontal bone regeneration with augmented dimensions comparable to GBR.

Indexed as

Alveolar Ridge AugmentationBone Morphogenetic Protein 2CollagenGuided Tissue Regeneration, PeriodontalTransforming Growth Factor betaAnimalsBone RegenerationBone SubstitutesCattleDogsHumansMembranes, ArtificialMineralsOsteogenesisRandom AllocationRecombinant ProteinsBio-OssBone Morphogenetic Protein 2Bone SubstitutesCollagenMembranes, ArtificialMineralsrecombinant human bone morphogenetic protein-2Recombinant ProteinsTransforming Growth Factor betaanimal studybone augmentationcollagen matrixguided bone regenerationrecombinant human bone morphogenic protein

Identifiers

PMID42414004
PMCPMC13581472

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.