ArticleInternational journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience2026
Abscisic Acid Enhances Hippocampal Neuroplasticity and Rescues Learning and Memory Deficits in a Valproate-Induced Rat Model of Autism.
Article in International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
objectivesThis study investigated the possible protective effects of abscisic acid (ABA), a naturally occurring phytohormone with incipient neuromodulatory properties, to alleviate cognitive and neurological alterations in a valproate (VPA)-induced rat model of autism.
methodsABA was injected intra-CA1 hippocampal (0.5, 1, 1.5 μg/rat) in both VPA-exposed and control rats. Spatial learning and memory retention was validated by Morris water maze (MWM). Additionally, hippocampal levels of oxidative stress biomarkers-hydrogen peroxide (H
resultsVPA-exposed rats exhibited significant deficits in learning and memory, alongside elevated hippocampal oxidative stress and downregulation of BDNF/TrkB and PI3K/AKT signalling. ABA treatment dose-dependently reversed learning and memory impairments. Moreover, ABA (1.5 μg/rat) significantly reduced H DISCUSSION: Overall, our results highlight the promising potential of ABA as a treatment for ASD while emphasising the necessity for more research to entirely elucidate its underlying mechanisms.
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