Evidence map›Paper›PMID 42413914›Full record

ArticleACS synthetic biology2026

Vision and Development of a Design, Implementation, and Verification Automation (DIVA) Software Platform for DNA Construction.

Hector Plahar, Stephen D Lane, Nina Stawski, Lisa Simirenko, Manjiri Tapaswi, Rita Kuo, Garima Goyal, Nathan J Hillson, Christopher J Petzold

Abstract read
In one paragraph

Article in ACS synthetic biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Hector PlaharDOE Agile BioFoundry, Emeryville, California94608, United States.
Stephen D LaneDOE Agile BioFoundry, Emeryville, California94608, United States.
Nina StawskiDOE Joint BioEnergy Institute, Emeryville, California94608, United States.
Lisa SimirenkoDOE Joint Genome Institute, Lawrence Berkeley National Laboratory, Berkeley, California94720, United States.
Manjiri TapaswiDOE Joint BioEnergy Institute, Emeryville, California94608, United States.
Rita KuoDOE Agile BioFoundry, Emeryville, California94608, United States.
Garima GoyalDOE Agile BioFoundry, Emeryville, California94608, United States.
Nathan J HillsonDOE Agile BioFoundry, Emeryville, California94608, United States.ORCID 0000-0002-9169-3978
Christopher J PetzoldDOE Agile BioFoundry, Emeryville, California94608, United States.ORCID 0000-0002-8270-5228

Funding

Bioenergy Technologies Office DE-AC02-05CH11231Biological and Environmental Research DE-AC02-05CH11231
6 · The paper itself

Abstract

DNA construction, while a prerequisite to many biological endeavors, is often a time-consuming distraction from an individual's primary research objectives. We envisioned that with the right software infrastructure and cultural mindset, a single person could execute in parallel the batched DNA construction tasks of an entire research institute, at scales realizing efficiency gains through process and laboratory automation. In pursuit of this vision, we developed the Design, Implementation, and Verification Automation (DIVA) software platform. DIVA's web interface enables researchers to design DNA constructs (using visual biological computer-aided design tools and biological parts repositories), submit designs for construction to dedicated staff, and track DNA construction as it progresses. DIVA supports the dedicated staff through the DNA construction process and records both successful and unsuccessful attempts toward improving the overall process. The platform is publicly available at public-diva.jbei.org and its open-source code through github.com/JBEI/DIVA.

Indexed as

DNASoftwareAutomationComputer-Aided DesignDNABioCADcombinatorial designcomputer-aided manufacturingdesign implementation verification automationDIVADNA construction

Identifiers

PMID42413914
PMCPMC13505335

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.