Evidence map›Paper›PMID 42413691›Full record

Trial reportAcademic pediatrics

Smart Inhaler Randomized Controlled Trial for Improving Inhaler Technique in Adolescents With Intellectual and Developmental Disabilities and Asthma.

Sophia Park, Alexis Deavenport-Saman, My H Vu, Ramon Durazo-Arvizu, Hyunbin Park, Jeanne Delgado, Christine B Mirzaian, Caitlin Sayegh, Naydelli Mendoza, Jasmine Osumo and 3 more

Abstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Academic pediatrics. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Sophia ParkDivision of General Pediatrics (S Park, A Deavenport-Saman, H Park, J Delgado, C Mirzaian, N Mendoza, M Enciso, A Torres, and L Yin), Children's Hospital Los Angeles, Los Angeles, Calif; Department of Pediatrics (S Park, A Deavenport-Saman, R Durazo-Arvizu, J Delgado, C Mirzaian, C Sayegh, and L Yin), University of Southern California Keck School of Medicine, Los Angeles, Calif.
Alexis Deavenport-SamanDivision of General Pediatrics (S Park, A Deavenport-Saman, H Park, J Delgado, C Mirzaian, N Mendoza, M Enciso, A Torres, and L Yin), Children's Hospital Los Angeles, Los Angeles, Calif; Department of Pediatrics (S Park, A Deavenport-Saman, R Durazo-Arvizu, J Delgado, C Mirzaian, C Sayegh, and L Yin), University of Southern California Keck School of Medicine, Los Angeles, Calif. Electronic address: adeavenport@chla.usc.edu.
My H VuBiostatistics and Data Analysis Core (M Vu and R Durazo-Arvizu), The Saban Research Institute, Children's Hospital Los Angeles, Los Angeles, Calif.
Ramon Durazo-ArvizuDepartment of Pediatrics (S Park, A Deavenport-Saman, R Durazo-Arvizu, J Delgado, C Mirzaian, C Sayegh, and L Yin), University of Southern California Keck School of Medicine, Los Angeles, Calif; Biostatistics and Data Analysis Core (M Vu and R Durazo-Arvizu), The Saban Research Institute, Children's Hospital Los Angeles, Los Angeles, Calif.
Hyunbin ParkDivision of General Pediatrics (S Park, A Deavenport-Saman, H Park, J Delgado, C Mirzaian, N Mendoza, M Enciso, A Torres, and L Yin), Children's Hospital Los Angeles, Los Angeles, Calif; Division of Pulmonology and Sleep Medicine (H Park), Children's Hospital Los Angeles, Los Angeles, Calif.
Jeanne DelgadoDivision of General Pediatrics (S Park, A Deavenport-Saman, H Park, J Delgado, C Mirzaian, N Mendoza, M Enciso, A Torres, and L Yin), Children's Hospital Los Angeles, Los Angeles, Calif; Department of Pediatrics (S Park, A Deavenport-Saman, R Durazo-Arvizu, J Delgado, C Mirzaian, C Sayegh, and L Yin), University of Southern California Keck School of Medicine, Los Angeles, Calif; AltaMed Institute for Health Equity, Los Angeles (J Delgado and J Osumo), Los Angeles, Calif.
Christine B MirzaianDivision of General Pediatrics (S Park, A Deavenport-Saman, H Park, J Delgado, C Mirzaian, N Mendoza, M Enciso, A Torres, and L Yin), Children's Hospital Los Angeles, Los Angeles, Calif; Department of Pediatrics (S Park, A Deavenport-Saman, R Durazo-Arvizu, J Delgado, C Mirzaian, C Sayegh, and L Yin), University of Southern California Keck School of Medicine, Los Angeles, Calif.
Caitlin SayeghDepartment of Pediatrics (S Park, A Deavenport-Saman, R Durazo-Arvizu, J Delgado, C Mirzaian, C Sayegh, and L Yin), University of Southern California Keck School of Medicine, Los Angeles, Calif; Division of Adolescent and Young Adult Medicine (C Sayegh), Children's Hospital Los Angeles, Los Angeles, Calif.
Naydelli MendozaDivision of General Pediatrics (S Park, A Deavenport-Saman, H Park, J Delgado, C Mirzaian, N Mendoza, M Enciso, A Torres, and L Yin), Children's Hospital Los Angeles, Los Angeles, Calif.
Jasmine OsumoAltaMed Institute for Health Equity, Los Angeles (J Delgado and J Osumo), Los Angeles, Calif.
Megan EncisoDivision of General Pediatrics (S Park, A Deavenport-Saman, H Park, J Delgado, C Mirzaian, N Mendoza, M Enciso, A Torres, and L Yin), Children's Hospital Los Angeles, Los Angeles, Calif.
Aneli TorresDivision of General Pediatrics (S Park, A Deavenport-Saman, H Park, J Delgado, C Mirzaian, N Mendoza, M Enciso, A Torres, and L Yin), Children's Hospital Los Angeles, Los Angeles, Calif.
Larry YinDivision of General Pediatrics (S Park, A Deavenport-Saman, H Park, J Delgado, C Mirzaian, N Mendoza, M Enciso, A Torres, and L Yin), Children's Hospital Los Angeles, Los Angeles, Calif; Department of Pediatrics (S Park, A Deavenport-Saman, R Durazo-Arvizu, J Delgado, C Mirzaian, C Sayegh, and L Yin), University of Southern California Keck School of Medicine, Los Angeles, Calif.

Funding

Southern California Clinical and Translational Science InstituteUL1TR001855 · NCATS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI Thomas A Buchanan, Michele D. Kipke · 2016 to 2026
$81.3M
NCATS NIH HHS UL1 TR001855
6 · The paper itself

Abstract

objectiveTo evaluate the feasibility, acceptability, and usability of a real-time feedback smart inhaler for adolescents with intellectual and developmental disabilities (IDD) and asthma; assess preliminary efficacy in improving metered-dose inhaler (MDI) technique; and explore device-measured proficiency and lung function in the full cohort, alongside a predefined autism subgroup analysis.

methodsWe conducted a single-center, single-blind, pilot randomized controlled trial involving 28 adolescents (aged 10-17 years) with IDD and asthma. Participants were randomized 1:1 to an intervention group using smart inhalers with audiovisual feedback for 8 weeks, or a control group receiving standard asthma education. Primary outcomes were parent- and adolescent-reported feasibility, acceptability, and usability. The secondary outcome was observer-rated inhaler proficiency. Exploratory outcomes were full-cohort device-measured inhaler proficiency and lung function (FEV

resultsThe intervention was feasible, acceptable, and usable, yielding high parent and adolescent motivation and satisfaction. The intervention group demonstrated significantly greater improvement in observer-rated Inhaler Proficiency Scale scores from baseline to week 8 compared to the control group (mean difference 1.5 points; 95% CI: 0.4-2.6; P = .02). Exploratory outcomes showed no significant between-group differences in lung function or device-measured proficiency. However, the autism subgroup exhibited inhaler technique improvements consistent with the broader cohort.

conclusionsSmart inhalers are feasible, acceptable, and usable for adolescents with IDD, and are associated with significant improvement in observer-rated inhaler technique when combined with standard clinical education. Given the inherent challenges of spirometry in this population, future studies should incorporate effort-independent clinical assessment measures.

Indexed as

Anti-Asthmatic AgentsAsthmaDevelopmental DisabilitiesIntellectual DisabilityMetered Dose InhalersAdherence InterventionsAdministration, InhalationAdolescentChildFeasibility StudiesFemaleHumansMalePatient Education as TopicPatient SatisfactionPilot ProjectsAnti-Asthmatic Agentsadolescentasthmadigital healthintellectual disabilitymetered dose inhalers

Identifiers

PMID42413691
PMCPMC13449947

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.