ArticleBiomedica : revista del Instituto Nacional de Salud2026
Unusual gastrointestinal histoplasmosis with jejunal perforation in a 57-year-old patient from Bogotá: Case report.
Article in Biomedica : revista del Instituto Nacional de Salud, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Histoplasmosis is an endemic fungal infection caused by Histoplasma species. Disseminated forms, although rare, often involve the gastrointestinal tract and primarily affect immunocompromised patients. This article presents an unusual case of gastrointestinal histoplasmosis with jejunal perforation. A 57-year-old man presented with chronic abdominal pain, intermittent fever, cough, diaphoresis, nausea, and rapid weight loss. Findings on computed tomography scans showed thickening and malignant lesions in the intestine, further evaluated through laparotomy, in addition to pulmonary involvement. Jejunal perforation and septic shock were identified and treated with antibiotics. The clinical course was unfavorable, resulting in patient's death. Peritoneal liquid cultures and hemocultures were negative, but the biopsy histological analysis revealed the presence of intracellular yeasts compatible with Histoplasma spp. This case highlights the importance of considering invasive fungal infections in apparently immunocompetent critically ill patients and reassessing diagnostic methods to ensure timely and effective treatment.
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