ReviewScience signaling2026
Convergent mechanisms in Wnt and Hedgehog signaling.
Review in Science signaling, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
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0 citing papers in PubMed.
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Authors and funding
3 authors.
Funding
Abstract
The Wnt and Hedgehog (Hh) pathways are cornerstones of tissue and organ biology and are implicated in numerous diseases. Wnt and Hh signaling share multiple mechanistic features, including lipidated ligands, specialized ligand delivery systems, atypical G protein-coupled receptors, and transcriptional effectors controlled by phosphorylation-dependent inhibition. Here, we highlight work showing that tethered pseudosubstrate inhibition of kinases is a core mechanism governing intracellular signal transmission in both pathways. These parallels suggest that Wnt and Hh have converged on a shared regulatory logic, enabling them to encode specific functional outputs while using molecules shared with numerous other cascades. This mode of signaling may extend to other pathways where cell-surface receptors directly regulate kinase activity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.