ArticleOdontology2026
miR-4485-5p regulates the progression of periodontitis by targeting CDK9.
Article in Odontology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Periodontitis leads to tooth loss, affecting human oral health. The role of microRNA (miRNA) in periodontitis has received increasing attention. This study aims to explore the role of miR-4485-5p in the progression of periodontitis. Baseline clinical data were collected from 93 periodontitis participants and 85 periodontally healthy subjects. The diagnostic value of miR-4485-5p and its correlation with severity were evaluated by the ROC curve and Pearson regression. miR-4485-5p and target gene expression were detected by RT-qPCR and Western blot. The periodontitis cell model was constructed by treating hPDLSCs with P. gingivalis LPS. Cell viability and inflammatory factor levels were detected by CCK-8 and ELISA. The target genes of miR-4485-5p were identified by databases and verified by dual-luciferase reporter assay. miR-4485-5p is downregulated in the saliva of patients with periodontitis. miR-4485-5p effectively distinguishes periodontitis and is negatively correlated with plaque index (PI), bleeding index (BI), probing depth (PD), and clinical attachment level (CAL). LPS inhibits the expression of miR-4485-5p in hPDLSCs, suppresses cell proliferation, and promotes the release of TNF-α, IL-1β, IL-6, and IL-8. Overexpression of miR-4485-5p promotes cell proliferation and inhibits the secretion of inflammatory factors in LPS-induced hPDLSCs. As a target of miR-4485-5p, CDK9 reversed the effects of miR-4485-5p on cell proliferation and inflammatory factors. miR-4485-5p could be the diagnostic biomarker of periodontitis and is correlated with the severity of periodontitis. Overexpression of miR-4485-5p could reverse the cell viability and inflammation in LPS-induced hPDLSCs. While CDK9 could eliminate the effect of miR-4485-5p.
Indexed as
Identifiers
42412386What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.