ReviewOdontology2026
Epigenetic mechanisms of gingival aging: biological basis, periodontal implications, and therapeutic perspectives.
Review in Odontology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
Gingival aging has become increasingly important as increasing number of individuals retain their natural dentition into older age. Beyond epithelial thinning, connective tissue remodeling, vascular alterations, and delayed healing, aging gingiva may be affected by immunosenescence, inflammaging, cellular senescence, and epigenetic dysregulation. Epigenetic mechanisms, including DNA methylation, histone modification, and microRNA-mediated regulation, may link chronological aging and cumulative environmental exposures to altered inflammatory signaling, extracellular matrix turnover, oxidative stress responses, and tissue repair. This narrative review summarizes current knowledge of the structural, immunological, vascular, and epigenetic features of gingival aging, with particular emphasis on the relationship among biological aging, epigenetic regulation, and periodontal disease susceptibility. The review also highlights the implications of gingival aging for frailty, oral-systemic health, and future preventive or therapeutic strategies. Because gingiva-specific longitudinal human evidence remains limited, epigenetic biomarkers and aging-targeted interventions should be regarded as promising yet investigational approaches requiring further validation.
Indexed as
Identifiers
42412383What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.