ArticleAnnals of biomedical engineering2026
Effects of Simulated Body-Mass Reduction on Peak Knee Joint Loads During Daily Functional Activities.
Article in Annals of biomedical engineering, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
purposeWhile weight management is a primary recommendation for individuals with or at risk of knee osteoarthritis (KOA), the isolated mechanical impact of body-mass reduction on knee joint loads remains incompletely understood. This study aimed to quantify the acute biomechanical responses of peak knee joint loads to simulated body-mass reduction across various daily functional activities.
methodsEleven healthy adults performed level walking, stair ascent, stair descent, stand-to-sit, and sit-to-stand under a simulated overweight baseline and three unloading conditions created by progressively reducing externally added loads using weighted vests and limb straps. Motion data were recorded using a motion capture system, and OpenSim was used to estimate tibiofemoral contact force, patellofemoral contact force, and knee joint moment.
resultsSimulated body-mass reduction generally reduced peak knee joint loads in a task-dependent manner. Peak tibiofemoral contact force decreased significantly across all tasks (p < 0.05), with pronounced reductions in high-flexion activities. Patellofemoral contact force and knee joint moment also decreased, although responses varied by task and variable. Furthermore, the magnitude of joint load reduction varied across the progressive stages of external unloading.
conclusionThe acute mechanical effects of simulated body-mass reduction on knee joint loads vary significantly across different functional tasks and joint compartments. These findings focus on the mechanical contribution of body-mass reduction to knee joint loading, providing quantitative biomechanical evidence to inform load-management strategies for individuals with excessive knee loading.
Indexed as
Identifiers
42412277What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.