Evidence map›Paper›PMID 42412218›Full record

ReviewIntensive care medicine2026

60 years of ARDS and the evolution of extracorporeal lung support - from ECMO to ECCO

Shannon M Fernando, Daniel Brodie, Arthur S Slutsky, Darryl Abrams, Cara Agerstrand, Luigi Camporota, Eddy Fan, Niall D Ferguson, Carol L Hodgson, Catherine L Hough and 8 more

Abstract readReview
PubMed Publisher
In one paragraph

Review in Intensive care medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Shannon M Fernando *Department of Critical Care Medicine, Queen's University, Kingston, Canada.ORCID http://orcid.org/0000-0003-4549-4289
Daniel Brodie *Department of Medicine, Division of Pulmonary and Critical Care Medicine, The Johns Hopkins University School of Medicine, Baltimore, USA. danielbrodie@jhu.edu.
Arthur S SlutskyInterdepartmental Division of Critical Care Medicine, University of Toronto, Toronto, Canada.
Darryl AbramsDepartment of Medicine, Division of Pulmonary, Allergy, and Critical Care Medicine, Columbia University College of Physicians and Surgeons, New York, USA.
Cara AgerstrandDepartment of Medicine, Division of Pulmonary, Allergy, and Critical Care Medicine, Columbia University College of Physicians and Surgeons, New York, USA.
Luigi CamporotaDepartment of Critical Care Medicine, Guy's and St Thomas' NHS Foundation Trust, London, UK.
Eddy FanInterdepartmental Division of Critical Care Medicine, University of Toronto, Toronto, Canada.
Niall D FergusonInterdepartmental Division of Critical Care Medicine, University of Toronto, Toronto, Canada.
Carol L HodgsonAustralian and New Zealand Intensive Care-Research Centre, School of Public Health and Preventive Medicine, Monash University, Victoria, Australia.
Catherine L HoughDivision of Pulmonary and Critical Care Medicine, Department of Medicine, Oregon Health and Sciences University, Portland, USA.
Gennaro MartucciDepartment of Anesthesia and Intensive Care, Istituto Mediterraneo Per I Trapianti E Terapie Ad Alta Specializzazione (IRCCS-ISMETT), Palermo, Italy.
Laveena MunshiInterdepartmental Division of Critical Care Medicine, University of Toronto, Toronto, Canada.
Marlies OstermannDepartment of Intensive Care, King's College London, Guy's and St Thomas' Hospital, London, UK.
Brijesh V PatelRoyal Brompton and Harefield Hospitals, Guy's and St Thomas' NHS Foundation Trust, London, UK.
Matthieu SchmidtInstitute of Cardiometabolism and Nutrition, Sorbonne University, INSERM, UMRS 1166-ICAN, Paris, France.
Kiran ShekarAdult Intensive Care Services, The Prince Charles Hospital, Metro North Health Service, Brisbane, Australia.
Alexander SupadyFaculty of Medicine, Interdisciplinary Medical Intensive Care, Medical Center, University of Freiburg, Freiburg, Germany.
Alain CombesInstitute of Cardiometabolism and Nutrition, Sorbonne University, INSERM, UMRS 1166-ICAN, Paris, France.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Extracorporeal life support (ECLS), including venovenous extracorporeal membrane oxygenation (VV-ECMO) and extracorporeal carbon dioxide removal (ECCO₂R), is an established treatment for selected patients with acute respiratory distress syndrome (ARDS). In this review, on the 60th anniversary of ARDS, we review the evolution of ECLS as a support strategy in ARDS, the evidence surrounding its efficacy, factors associated with prognosis, management of patients on ECLS, associated complications, and long-term outcomes among survivors. We also highlight existing areas of uncertainty, and ongoing clinical research that will define the next decade and beyond of ECLS for ARDS.

Indexed as

Extracorporeal Membrane OxygenationRespiratory Distress SyndromeCarbon DioxideHistory, 20th CenturyHistory, 21st CenturyHumansCarbon DioxideAcute respiratory distress syndromeExtracorporeal life supportExtracorporeal membrane oxygenationRespiratory failure

Identifiers

PMID42412218

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.