ArticleGraefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie2026
Impact of image enhancement on grading agreement of plus disease features in retinopathy of prematurity.
Article in Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundTo determine whether targeted image enhancement improves intergrader agreement in assessing vascular features of plus disease in retinopathy of prematurity (ROP), and to identify which specific features and clinical subgroups benefit most.
methodsThis prospective image grading study included 48 eyes from preterm infants undergoing ROP screening at a tertiary care center. All eyes were imaged with the RetCam Envision system. For each eye, five fundus images centered on the optic disc were selected and underwent standardized enhancement combining blue-channel attenuation and CLAHE-based contrast optimization. Five pediatric ophthalmologists with varying ROP experience independently evaluated raw and enhanced image sets in two grading rounds, one month apart. For each quadrant, graders recorded the presence or absence of arterial and venous tortuosity and dilation. Intergrader agreement was quantified using unweighted and weighted Fleiss' kappa and overall percentage agreement.
resultsImage enhancement significantly improved intergrader agreement (mean weighted agreement: 61.5% for raw vs. 67.8% for enhanced images, p < 0.05). The greatest improvements were observed for arterial tortuosity (+ 11.9%) and vein tortuosity (+ 6.5%). Nasal quadrants showed the most pronounced benefit. Subgroup analyses revealed larger improvements in borderline pre-plus cases and in eyes that had previously received treatment.
conclusionsTargeted image enhancement improves intergrader agreement in the evaluation of plus disease in ROP, especially for diagnostically challenging features and regions. The strongest effect is seen in borderline and treated cases, supporting the integration of standardized preprocessing techniques to enhance diagnostic objectivity for both clinicians and AI-assisted systems.
Indexed as
Identifiers
42412199What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.