Evidence map›Paper›PMID 42412170›Full record

ReviewZeitschrift fur Rheumatologie2026

[Immune cell populations in rheumatoid arthritis and giant cell arteritis].

Laurin Braune, Caroline Schmidt

Abstract readEnglish AbstractReview
PubMed Publisher
In one paragraph

Review in Zeitschrift fur Rheumatologie, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Laurin BrauneKlinikbereich Rheumatologie, Klinik und Poliklinik für Endokrinologie, Nephrologie, Rheumatologie, Universitätsklinikum Leipzig, Liebigstraße 21, 04103, Leipzig, Deutschland.
Caroline SchmidtKlinikbereich Rheumatologie, Klinik und Poliklinik für Endokrinologie, Nephrologie, Rheumatologie, Universitätsklinikum Leipzig, Liebigstraße 21, 04103, Leipzig, Deutschland. caroline.schmidt@medizin.uni-leipzig.de.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundRheumatoid arthritis (RA) and giant cell arteritis (GCA) are systemic autoimmune diseases with distinct clinical manifestations that are driven by dysregulation of multiple cell populations of the innate and adaptive immune systems.

objectiveThe aim of this work is to describe and compare the role of central immune cell populations in RA and GCA. MATERIAL AND

methodsThis review is based on a comprehensive literature search in PubMed. Recent publications on immune cell populations in RA and GCA were assessed for their pathogenic significance and therapeutic implications.

resultsBoth diseases show complex interactions between T cells, B cells, and cells of the innate immune system. A common feature is an imbalance between pro-inflammatory and regulatory mechanisms, ultimately leading to chronic inflammation and tissue damage. Key differences include a dominant role of autoreactive lymphocytes and autoantibodies in RA, whereas dendritic cells and T cell-mediated vascular inflammation are the main drivers in GCA.

conclusionA deeper understanding of these immune cell populations enables new treatment strategies and could be particularly relevant for patients who do not adequately respond to current forms of treatment.

Indexed as

Arthritis, RheumatoidGiant Cell ArteritisModels, ImmunologicalDendritic CellsEvidence-Based MedicineHumansImmunity, InnateT-LymphocytesAutoimmune diseasesDysregulationImmune cellsImmune systemInflammation

Identifiers

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.