Evidence map›Paper›PMID 42412124›Full record

ArticleJournal of neuro-oncology2026

Rethinking white matter-tumor interaction: a tractography based analysis of associations between fractional anisotropy and morphometry in the IFOF and arcuate fasciculus.

Roberto Altieri, Lorenzo Ugga, Andrea Bianconi, Stefano Caneva, Ferdinando Caranci, Giovanni Cirillo, Fabio Cofano, Sergio Corvino, Oreste de Divitiis, Giuseppe Maria Della Pepa and 22 more

Abstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of neuro-oncology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

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4 · The record

Corrections and comments

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5 · Who and what money

Authors and funding

32 authors.

Roberto Altieri *Multidisciplinary Department of Medical-Surgical and Dental Specialties, University of Campania Luigi Vanvitelli, 80131, Naples, Italy. roberto.altieri@unicampania.it.
Lorenzo Ugga *Department of Advanced Medical and Surgical Sciences, School of Medical Sciences, University of Campania Luigi Vanvitelli, P.zza L. Miraglia 2, 80138, Naples, Italy.
Andrea BianconiDepartment of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health (DINOGMI), University of Genova, 16132, Genova, Italy.
Stefano CanevaDepartment of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health (DINOGMI), University of Genova, 16132, Genova, Italy.
Ferdinando CaranciDepartment of Advanced Medical and Surgical Sciences, School of Medical Sciences, University of Campania Luigi Vanvitelli, P.zza L. Miraglia 2, 80138, Naples, Italy.
Giovanni CirilloLaboratory of Morphology of Neuronal Network, Department of Public Medicine, University of Campania Luigi Vanvitelli, 80138, Naples, Italy.
Fabio CofanoNeurosurgery Unit, Department of Neuroscience Rita Levi Montalcini, University of Turin, 10126, Turin, Italy.
Sergio CorvinoDivision of Neurosurgery, Ospedale del Mare Hospital, 80147, Naples, Italy.
Oreste de DivitiisDepartment of Neuroscience and Reproductive and Odontostomatological Sciences, Neurosurgical Clinic, University of Naples Federico II, Via Pansini 5, 80131, Naples, Italy.
Giuseppe Maria Della PepaInstitute of Neurosurgery, Fondazione Policlinico Universitario A. Gemelli IRCCS, Catholic University, 00168, Rome, Italy.
Donatella FrancoDepartment of Advanced Medical and Surgical Sciences, School of Medical Sciences, University of Campania Luigi Vanvitelli, P.zza L. Miraglia 2, 80138, Naples, Italy.
Ciro De LucaLaboratory of Morphology of Neuronal Network, Department of Public Medicine, University of Campania Luigi Vanvitelli, 80138, Naples, Italy.
Pietro FiaschiDepartment of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health (DINOGMI), University of Genova, 16132, Genova, Italy.
Gianluca GalieriInstitute of Neurosurgery, Fondazione Policlinico Universitario A. Gemelli IRCCS, Catholic University, 00168, Rome, Italy.
Diego GarbossaNeurosurgery Unit, Department of Neuroscience Rita Levi Montalcini, University of Turin, 10126, Turin, Italy.
Giuseppe La RoccaInstitute of Neurosurgery, Fondazione Policlinico Universitario A. Gemelli IRCCS, Catholic University, 00168, Rome, Italy.
Salvatore MarinoInstitute of Neurosurgery, Fondazione Policlinico Universitario A. Gemelli IRCCS, Catholic University, 00168, Rome, Italy.
Edoardo MazzucchiNeurosurgical Training Center and Brain Research, Mater Olbia Hospital, 07026, Olbia, Italy.
Grazia MennaInstitute of Neurosurgery, Fondazione Policlinico Universitario A. Gemelli IRCCS, Catholic University, 00168, Rome, Italy.
Antonio MezzogiornoLaboratory of Morphology of Neuronal Network, Department of Public Medicine, University of Campania Luigi Vanvitelli, 80138, Naples, Italy.
Alberto MorelloNeurosurgery Unit, Department of Neuroscience Rita Levi Montalcini, University of Turin, 10126, Turin, Italy.
Alessandro OliviInstitute of Neurosurgery, Fondazione Policlinico Universitario A. Gemelli IRCCS, Catholic University, 00168, Rome, Italy.
Michele PapaLaboratory of Morphology of Neuronal Network, Department of Public Medicine, University of Campania Luigi Vanvitelli, 80138, Naples, Italy.
Daniela PacellaDepartment of Public Health, University of Naples Federico II, Naples, Italy.
Rosellina RussoDepartment of Radiology, Neuroradiology Unit, Fondazione Policlinico Universitario A. Gemelli IRCCS, 00168, Rome, Italy.
Giovanni SabatinoInstitute of Neurosurgery, Fondazione Policlinico Universitario A. Gemelli IRCCS, Catholic University, 00168, Rome, Italy.
Giovanna SepeLaboratory of Morphology of Neuronal Network, Department of Public Medicine, University of Campania Luigi Vanvitelli, 80138, Naples, Italy.
Assunta VirtuosoLaboratory of Morphology of Neuronal Network, Department of Public Medicine, University of Campania Luigi Vanvitelli, 80138, Naples, Italy.
Giovanni VitaleNeurosurgery Unit, Regional Hospital San Carlo, Potenza, Italy.
Giuseppe VitaleRadiology Department, CTO Hospital, AORN dei Colli, 80131, Naples, Italy.
Gianluigi ZonaDepartment of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health (DINOGMI), University of Genova, 16132, Genova, Italy.
Manlio BarbarisiMultidisciplinary Department of Medical-Surgical and Dental Specialties, University of Campania Luigi Vanvitelli, 80131, Naples, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundWhite matter (WM) tract involvement represents a critical determinant of functional outcome in neuro-oncology. Although substantial advances in diffusion tensor imaging (DTI) and intraoperative mapping have improved characterization of WM organization, the relationship between microstructural integrity and morphometric alterations of associative fasciculi in different tumor histotypes remains incompletely understood. We investigated the association between fractional anisotropy (FA), volumetric and length parameters of the inferior fronto-occipital fasciculus (IFOF) and arcuate fasciculus (AF) across distinct intracranial tumor types.

methodsIn this multicenter retrospective study, 156 patients undergoing surgery for brain tumors were included. All lesions were located in proximity to the IFOF or AF and underwent preoperative deterministic tractography based on standardized DTI protocols. Linear mixed-effects models, adjusted for relevant covariates, assessed the association between FA and tract morphometry, including interaction terms for tumor type and hemisphere.

resultsHigher FA was strongly associated with both AF and IFOF tract volume (adjusted p < 0.001), whereas associations with tract length were weaker and not consistently significant. The association between FA and IFOF volume appeared stronger in gliomas than in metastases or meningiomas, suggesting potential histotype-related difference in WM involvement. The healthy hemisphere showed higher FA and morphometric measures than the tumor-affected side.

conclusionsFA was significantly associated with morphometric features of WM tract, particularly in infiltrative tumors. Integrating FA into preoperative assessment may enhance surgical planning and support strategies aimed at preserving functional connectivity.

Indexed as

Brain NeoplasmsDiffusion Tensor ImagingGliomaWhite MatterAdultAgedAnisotropyFemaleHumansImage Processing, Computer-AssistedMaleMiddle AgedNeural PathwaysRetrospective StudiesYoung AdultArcuate fascicleConnectomeGlioblastomaLow grade gliomaMeningiomaMetastasis

Identifiers

PMID42412124
PMCPMC13341889

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