ArticleJournal of neurophysiology2026
Separate dorsolateral prefrontal cortex regions participate in distinct large-scale networks differentially recruited for social and cognitive control functions.
Article in Journal of neurophysiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Human prefrontal cortex (PFC) is heterogeneous. In monkeys, side-by-side PFC regions, including within dorsolateral PFC (DLPFC), show distinct long-range anatomical projection profiles, raising the possibility that separate DLPFC regions might specialize as a consequence of the distributed networks in which they are embedded. Recent findings in humans provide evidence for PFC regions preferentially responding to scene (spatial) processing or language processing that are adjacent to distinct domain-flexible regions responding to traditional cognitive control demands. Here, we tested functional specialization of PFC regions linked to another domain-preferential network recruited by certain forms of social processing (theory-of-mind, ToM, tasks). Using within-individual precision neuroimaging approaches, two anatomically distinct DLPFC regions embedded within parallel distributed networks were identified within the idiosyncratic anatomy of each individual (
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