Observational studyJournal of cardiothoracic and vascular anesthesia2026
Intraoperative Lipoproteins Associated with Postoperative Delirium in a Prospective Observational Study of Older Adults Undergoing Cardiac Surgery.
Observational study in Journal of cardiothoracic and vascular anesthesia, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The trial behind it
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Who cites it
3 citing papers in PubMed.
- Long-chain polyunsaturated fatty acid lipid and oxylipin alterations in postoperative delirium after cardiac surgery.Journal of lipid research · 2026Article
- Targeted profiling of the serum proteome associates increased FGF-23 levels with postoperative delirium in cardiac surgical patients.NPJ dementia · 2026Article
- Investigating Microtubule-Associated Protein 2 in the Study of Postoperative Delirium.Delirium (Bielefeld, Germany) · 2026Article
Corrections and comments
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Authors and funding
15 authors.
Funding
Abstract
objectiveTo evaluate serum lipoproteins and other metabolites and their potential associations with the development of postoperative delirium.
designProspective observational cohort study.
settingSingle-site academic medical hospital.
participantsPatients age 60 years and older scheduled for major cardiac surgery with cardiopulmonary bypass (CPB).
interventionsDelirium assessments were performed at baseline and twice daily up to postoperative day 3. The primary outcome evaluated serum collected before surgery, at the start and end of CPB, and on postoperative day 1. MEASUREMENTS AND MAIN
resultsSixty-five patients were recruited, with 18% of subjects developing postoperative delirium within 3 days of surgery (10 of 57 subjects with complete cognitive assessments). Metabolomic analysis of serum revealed an association between the abundance of cholesterol in large high-density lipoprotein (L-HDL-C%) at the start of CPB and the development of postoperative delirium (odds ratio per standard deviation increment in biomarker concentration, 0.23; 95% confidence interval [CI], 0.08-0.66). Serum neurofilament light chain was inversely correlated with L-HDL-C% levels at the same time point (Spearman ρ, -0.39; 95% CI, -0.59 to -0.15) and was significantly higher at the end of CPB in subjects who developed delirium compared to subjects who did not develop delirium (median, 20.4 [interquartile range (IQR),16.1-25.4] pg/mL vs 11.9 [IQR, 7.9-16.9] pg/mL).
conclusionCirculating blood biomarkers during surgery may provide insight into postoperative cognitive outcomes and should be evaluated in larger cohorts.
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