Evidence map›Paper›PMID 42411783›Full record

ArticleProceedings (Baylor University. Medical Center)2026

Young-onset signet ring cell colorectal adenocarcinoma: demographics, clinicopathological profile, and survival analysis.

Marjan Khan, Sohawm Sengupta, Puneet Bansal, Kue Tylor Lee, Asim Ahmed, Asif Iqbal, Agha Wali, Hritvik Jain, Israr Khan, Basil Rasool and 8 more

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In one paragraph

Article in Proceedings (Baylor University. Medical Center), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Marjan KhanMarshfield Clinics, Marshfield, Wisconsin, USA.
Sohawm SenguptaMedical College of Georgia, Augusta, Georgia, USA.
Puneet BansalDepartment of Liver Transplant Surgery, Cleveland Clinic, Cleveland, Ohio, USA.
Kue Tylor LeeMedical College of Georgia, Augusta, Georgia, USA.
Asim AhmedMedical College of Georgia, Augusta, Georgia, USA.
Asif IqbalDepartment of Oncology, University of Toledo, Toledo, Ohio, USA.
Agha WaliDetroit Medical Center, Detroit, Michigan, USA.
Hritvik JainDepartment of Medicine, All India Institute of Medical Sciences, Jodhpur, India.
Israr KhanDepartment of Medicine, Insight Hospital and Medical Center, Chicago, Illinois, USA.
Basil RasoolDow International Medical College, Karachi, Pakistan.
Mumtaz Yaseen BalkhiDepartment of Immunology, Texas Tech University Health Sciences Center, Lubbock, Texas, USA.
Muhammad Samsoor ZarakDivision of Blood and Bone Marrow Transplant and Cellular Therapy, Stanford University Medical Center, Stanford, California, USA.
Mahrukh KhanTouro College of Osteopathic Medicine, Harlem, New York, USA.
Naga K Sucharita CheedellaDepartment of Hematology Oncology, Texas Tech University Health Sciences Center, Lubbock, Texas, USA.
Muhammad Ahmad NadeemDepartment of Liver Transplant Surgery, Cleveland Clinic, Cleveland, Ohio, USA.ORCID 0009-0007-7201-2886
Cecille NemethA. T. Still University Kirksville College of Osteopathic Medicine, Kirksville, Missouri, USA.
Amir Humza SohailDepartment of Surgery, University of New Mexico, Albuquerque, New Mexico, USA.
Asad UllahDepartment of Pathology, Texas Tech University Health Sciences Center, Lubbock, Texas, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundSignet ring cell carcinoma (SRCC), a rare subtype of colorectal adenocarcinoma, is associated with high rates of metastasis at presentation and poor prognosis. This study highlights demographic patterns, survival outcomes, and prognostic factors in young-onset SRCC.

methodsA retrospective analysis of SRCC patients <50 years was conducted using the Surveillance, Epidemiology, and End Results database (2000-2020).

resultsThere was a high prevalence of SRCC in young patients, with a median age at diagnosis of 41.0 years. A significant proportion of cases were in individuals ages 36 to 50. The rectum was the most common primary site (29.1%), and the liver was the most frequent site of metastasis at presentation (8.9% of patients with known metastases). Surgery combined with adjuvant chemotherapy yielded the highest 5-year survival (24.4%; 95% confidence interval [CI], 22.1-26.7), compared with chemotherapy alone (2.6%; 95% CI, 1.2-4.0). Multivariate analysis identified advanced stage, nodal positivity, distant metastases (hazard ratio 7.02; 95% CI, 4.66-10.56), and larger tumor size as significant adverse prognostic factors (all

conclusionsColorectal SRCC is an aggressive malignancy that disproportionately affects patients <50 years and frequently presents at advanced stages, underscoring the importance of earlier screening.

Indexed as

Carcinoma, Signet Ring CellColorectal NeoplasmsAdenocarcinomaAdultAge of OnsetFemaleHumansMaleMiddle AgedPrognosisRetrospective StudiesSEER ProgramSurvival AnalysisColorectalepidemiologyprognosisscreeningSEERsignet ring cell carcinoma

Identifiers

PMID42411783
PMCPMC13523951

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.