ArticleThe British journal of nutrition2026
Association of alcohol consumption with circulating biomarkers of atrial fibrillation-related pathways in a population at high cardiometabolic risk.
Article in The British journal of nutrition, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
The effect of alcohol consumption on atrial fibrillation risk remains controversial. Evaluating the association of alcohol consumption with atrial fibrillation-related biomarkers may help better understand the relevant mechanistic underpinnings. We studied participants from the PREDIMED-Plus study, a weight-loss randomised trial in metabolically unhealthy adults. N-terminal pro-B-type natriuretic protein, high-sensitivity troponin-T (hsTnT), high-sensitivity C-reactive protein (hsCRP), 3-nitrotyrosine and procollagen type 1 carboxy-terminal propeptide were measured in serum at baseline and years 3 and 5 of follow-up. We calculated average alcohol consumption in drinks/d (1 drink = 14 grams alcohol) with validated FFQ. Using multivariable models, we estimated cross-sectional and longitudinal associations of alcohol consumption with log-transformed biomarkers. Among 523 participants (mean age (sd): 65·1 (4·9) years, 40 % female), mean alcohol consumption was 1 drink/d. Cross-sectionally, alcohol consumption was not associated with cardiac biomarkers. Longitudinally, compared with non-consumers, heavy drinkers at baseline (≥ 4 drinks/d) had smaller increases in hsTnT (
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