ArticleAdvanced materials (Deerfield Beach, Fla.)2026
DNA-Regulated Catalytic-Plasmonic Colocalization Enables Synergistic Signal Amplification in SERS and Nanozyme-Based Sensors.
Article in Advanced materials (Deerfield Beach, Fla.), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
The critical need for accessible disease monitoring underscores the urgency of developing advanced point-of-care testing (POCT). We present a DNA-regulated catalytic-plasmonic colocalization-based synergy coupling mechanism that resolved the spatiotemporal disjunction commonly present in conventional SERS-catalysis systems through programmed spatial confinement. Rolling circle amplification-derived DNA nanocages were employed as programmable spatial regulators to precisely position Au@Pt nanozymes within plasmonic hotspots via base pair encoded hybridization, thereby enforcing spatial and temporal consistency between catalytic generation of Raman-active species and electromagnetic field enhancement. This strategy integrated coordinated interface, pore, and interlayer confinement, enabling cross-scale signal amplification from molecular to microscale levels. As a result, it yielded exceptional SERS enhancement (an approximate 41-fold versus controls), sensitivity (10
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