Evidence map›Paper›PMID 42411043›Full record

ArticleDiagnostic cytopathology2026

Clinical and Cytopathological Significance of Intracytoplasmic Lumina and Immunohistochemical Mucin Expression in Non-Muscle-Invasive Urothelial Carcinoma of the Bladder.

Toshie Terauchi, Thao Thanh Nguyen, Mao Takata, Ryo Shimizu, Yumi Tsubata, Yoshiiku Okanemasa, Katsuhito Miyazawa, Sohsuke Yamada, Akihiro Shioya

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Article in Diagnostic cytopathology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

9 authors.

Toshie TerauchiDepartment of Pathology and Laboratory Medicine, Kanazawa Medical University, Kahoku, Ishikawa, Japan.
Thao Thanh NguyenDepartment of Pathology and Laboratory Medicine, Kanazawa Medical University, Kahoku, Ishikawa, Japan.ORCID https://orcid.org/0009-0009-6782-7479
Mao TakataDepartment of Pathology and Laboratory Medicine, Kanazawa Medical University, Kahoku, Ishikawa, Japan.
Ryo ShimizuDepartment of Pathology and Laboratory Medicine, Kanazawa Medical University, Kahoku, Ishikawa, Japan.
Yumi TsubataDepartment of Pathology and Laboratory Medicine, Kanazawa Medical University, Kahoku, Ishikawa, Japan.
Yoshiiku OkanemasaDepartment of Pathology and Laboratory Medicine, Kanazawa Medical University, Kahoku, Ishikawa, Japan.
Katsuhito MiyazawaDepartment of Urology, Kanazawa Medical University Hospital, Kahoku, Ishikawa, Japan.ORCID https://orcid.org/0000-0002-0331-3753
Sohsuke YamadaDepartment of Pathology and Laboratory Medicine, Kanazawa Medical University, Kahoku, Ishikawa, Japan.ORCID https://orcid.org/0000-0003-2662-0024
Akihiro ShioyaDepartment of Pathology and Laboratory Medicine, Kanazawa Medical University, Kahoku, Ishikawa, Japan.ORCID https://orcid.org/0000-0002-1863-5368

Funding

the Kanazawa Medical University Hospital Grant-in-Aid for Allied Health Professionals H2021-9
6 · The paper itself

Abstract

backgroundIntracytoplasmic lumina (ICL) are mucin-containing structures identified in histological and cytological specimens of urothelial carcinoma and are associated with high-grade tumors and poor prognosis. However, their biological significance remains unclear. This study investigated mucin expression in ICL and its association with clinical, cytopathological, and prognostic features in non-muscle-invasive urothelial carcinoma of the bladder.

methodsA total of 105 cases of non-muscle-invasive urothelial carcinoma of the bladder diagnosed were examined. Immunohistochemical staining for MUC1, MUC2, MUC4, MUC5AC, and MUC6 was performed in 47 cases in which ICL were identified histologically, and the staining patterns of ICL and tumor cells were evaluated. The presence of ICL in urine cytology specimens was assessed, and its associations with tumor-specific survival and recurrence were analyzed statistically.

resultsICL were identified in 47 cases histologically and in 33 cases cytologically. ICL-positive tumors were more frequently observed in high-grade histology and were more often diagnosed as malignant or suspicious for malignancy in urine cytology. Immunohistochemically, MUC1 was the most frequently expressed mucin, with localization along the microvilli of the ICL lumen and within luminal mucin. Increased expression of MUC4 and MUC5AC showed a trend toward decreased survival.

conclusionICL in non-muscle-invasive urothelial carcinoma is more frequently observed in high-grade tumors and shows characteristic mucin expression patterns, particularly MUC1 localization within ICL structures. Increased expression of MUC4 and MUC5AC may be associated with unfavorable clinical outcomes. These findings suggest that combined evaluation of ICL and mucin expression may provide additional prognostic information in urothelial carcinoma.

Indexed as

Biomarkers, TumorCarcinoma, Transitional CellMucinsUrinary Bladder NeoplasmsAdultAgedAged, 80 and overFemaleHumansImmunohistochemistryMaleMiddle AgedNon-Muscle Invasive Bladder NeoplasmsPrognosisBiomarkers, TumorMucinsbladder cancerimmunohistochemistryintracytoplasmic luminamucin expressionprognostic markerurine cytologyurothelial carcinoma

Identifiers

PMID42411043
PMCPMC13532627

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