Evidence map›Paper›PMID 42410991›Full record

ArticleThe Journal of physiology2026

Protein kinase Cδ and pharmacomechanical coupling: Re-envisioning cerebral vascular control.

Nadia Haghbin, Michelle S M Kim, Mohammed El-Lakany, David M Richter, Dabasish Kumar Saha, Galina Yu Mironova, David A Steven, Jonathan C Lau, Mel Boulton, Nikolaos M Tsoukias and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of physiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Nadia HaghbinDepartment of Physiology & Pharmacology, Robarts Research Institute, Schulich School of Medicine, University of Western Ontario, London, Ontario, Canada.ORCID https://orcid.org/0009-0006-6495-2918
Michelle S M KimDepartment of Physiology & Pharmacology, Robarts Research Institute, Schulich School of Medicine, University of Western Ontario, London, Ontario, Canada.
Mohammed El-LakanyDepartment of Physiology & Pharmacology, Robarts Research Institute, Schulich School of Medicine, University of Western Ontario, London, Ontario, Canada.ORCID https://orcid.org/0000-0002-9139-3158
David M RichterDepartment of Physiology & Pharmacology, Robarts Research Institute, Schulich School of Medicine, University of Western Ontario, London, Ontario, Canada.
Dabasish Kumar SahaDepartment of Biomedical Engineering, Florida International University, Miami, FL, USA.ORCID https://orcid.org/0000-0002-2474-9767
Galina Yu MironovaDepartment of Physiology & Pharmacology, Robarts Research Institute, Schulich School of Medicine, University of Western Ontario, London, Ontario, Canada.
David A StevenDepartment of Clinical Neurological Sciences, Schulich School of Medicine and Dentistry, Western University, London, Ontario, Canada.
Jonathan C LauDepartment of Clinical Neurological Sciences, Schulich School of Medicine and Dentistry, Western University, London, Ontario, Canada.ORCID https://orcid.org/0000-0002-8452-8915
Mel BoultonDepartment of Clinical Neurological Sciences, Schulich School of Medicine and Dentistry, Western University, London, Ontario, Canada.
Nikolaos M TsoukiasDepartment of Biomedical Engineering, Florida International University, Miami, FL, USA.ORCID https://orcid.org/0000-0002-5164-9577
Donald G WelshDepartment of Physiology & Pharmacology, Robarts Research Institute, Schulich School of Medicine, University of Western Ontario, London, Ontario, Canada.ORCID https://orcid.org/0000-0001-5174-186X

Funding

Cerebral Microvascular Signaling and Neurovascular Coupling: An Integrated Approach to Investigate VCIDR01NS119971 · NINDS · FLORIDA INTERNATIONAL UNIVERSITY · PI TSOUKIAS, NIKOLAOS MICHAEL · 2021 to 2025
$2.6M
Heart and Stroke Foundation of Canada Grant-In-AidNatural Science and Engineering Council of Canada RGPIN/0465902917NINDS NIH HHS R01 NS119971NINDS NIH HHS RO1NS19971
6 · The paper itself

Abstract

Constrictor stimuli set arterial tone through coupling processes dependent (electromechanical) and independent (pharmacomechanical) of V

Indexed as

Cerebral ArteriesCerebrovascular CirculationProtein Kinase C-delta15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic AcidAnimalsHumansMaleMiceMice, Inbred C57BLVasoconstriction15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic AcidProtein Kinase C-deltaagonistarteriescerebral circulationfocal constrictionGPCRneurovascular couplingPKC

Identifiers

PMID42410991
PMCPMC13423129

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.