ArticleMedicine2026
ADL dependence may represent a potential pathway linking chronic lung disease and depression in the middle-aged and older adults: A prospective cross-national cohort study (STROBE).
Article in Medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Additive Burden of Low Peak Expiratory Flow and Sleep Disturbance on Incident Depressive Symptoms in Later Life: A Four-Cohort Longitudinal Study of 49,201 Participants.Healthcare (Basel, Switzerland) · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Previous studies have indicated that middle-aged and older adults with activities of daily living (ADL) dependence or chronic lung disease (CLD) are more susceptible to depression. This study aimed to explore the potential mediating role of ADL dependence. Data from the 2015 to 2020 China Health and Retirement Longitudinal Study (CHARLS), the 2014 to 2019 English Longitudinal Study of Ageing (ELSA), and the 2014 to 2020 Health and Retirement Study (HRS) were utilized for analysis. Spearman correlation analysis was performed to detect correlations among CLD, ADL dependence, and depression. Logistic regression was used to adjust for covariates, and mediation analysis was performed using nonparametric bootstrap and multiple imputation. A total of 18,554 participants, 5,418 from CHARLS, 4560 from ELSA, and 8576 from HRS, were included in this study. The incident depression rates in the CHARLS, ELSA, and HRS cohorts were 27.5%, 11.3%, and 13.4%, respectively. Spearman correlation analysis demonstrated significant associations among CLD, depression, and dependence in both basic ADL and instrumental ADL (P < .05). Across the 3 cohorts, the potential mediating effect of basic ADL dependence on the CLD-depression link accounted for 7.8% in CHARLS, 13.7% in ELSA, and 10.1% in HRS. For instrumental ADL dependence, the potential mediating effect proportions were 6.2% in CHARLS, 9.1% in ELSA, and 12.1% in HRS, respectively. ADL dependence may partially mediate the CLD-depression relationship across diverse populations. However, the effect is weak, and the value of ADL interventions in preventing depression is limited.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.