SynthesisMedicine2026
Correlation between temporomandibular disorders and the history of orthodontic treatment: A systematic review and meta-analysis.
Synthesis in Medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
backgroundThis study aimed to investigate the correlation between the occurrence and development of temporomandibular disorders (TMDs) and the history of orthodontic treatment.
methodsRandomized controlled trials and non-randomized controlled studies investigating the correlation between the occurrence and development of TMDs and the history of orthodontic treatment were included in this study. A comprehensive search was conducted in the 5 databases of PubMed, Scopus, Web of Science, Embase, and The Cochrane Library to collect the literature published from the establishment of each database to March 2025. Meanwhile, other manual retrieval methods were also adopted to search for additional pertinent literature. The corresponding bias risk assessment tools were used to evaluate the quality of the included studies. Meta-analysis was performed for data combination to obtain the odds ratio of the correlation between the 2. The Grading of Recommendations Assessment, Development and Evaluation (GRADE) system was used to assess the quality of evidence of the outcome indicators.
results5 studies finally met the inclusion criteria: 2 were prospective cohort studies, 2 were case-control studies, and 1 was a cross-sectional study. The total sample size comprised 6971 people, with 3165 males and 3806 females, respectively. The results of the Meta-analysis showed that there was no statistically significant correlation between TMDs and the history of orthodontic treatment (I2 = 71%, odds ratio = 1.12, 95% confidence interval = 0.67 to 1.89, P = .66). The evaluation result of the certainty of evidence was of very low quality.
conclusionBased on the current limited evidence, this study shows that there is no significant correlation between TMDs and the history of orthodontic treatment. Due to the limited certainty of the evidence, the interpretation of the result must be approached with caution. High-quality clinical studies are still needed in the future to supplement this research topic, so as to formulate high-level evidence-based clinical guidelines and optimize clinical decision-making and diagnosis and treatment services for patients. In order to prevent needless doctor-patient conflicts, orthodontists should closely monitor the potential risk of TMDs in patients with malocclusion in clinical practice.
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