ArticleMedicine2026
The causal associations of serum uric acid levels and gout with the risk of acute pancreatitis: A bidirectional Mendelian randomization study.
Article in Medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
6 authors.
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Abstract
This study investigates the causal links between serum uric acid (UA), gout, and the risk of acute pancreatitis (AP) using a bidirectional 2-sample Mendelian randomization analysis of genome-wide association studies data. The primary inverse variance weighted method indicated that genetically predicted higher serum UA levels are causally associated with an increased risk of AP (odds ratio [OR] = 1.194, 95% confidence interval [CI]: 1.020-1.399, P = .027). Conversely, the reverse Mendelian randomization analysis suggested a potential weak inverse association, with genetically predicted AP linked to slightly lower serum UA levels (OR = 0.989, 95% CI: 0.978-1.000, P = .043). Regarding gout, we found no statistically significant evidence to support a causal relationship in either direction: from gout to AP (OR = 0.015, 95% CI: 0.000-1.231, P = .062) or from AP to gout (OR = 1.001, 95% CI: 1.000-1.002, P = .217). These results support a causal role for elevated UA in AP pathogenesis, suggesting its relevance in risk assessment, while gout itself does not appear to be a causal factor for AP.
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