Evidence map›Paper›PMID 42410730›Full record

ArticleAlzheimer's & dementia : the journal of the Alzheimer's Association2026

Genetic architecture of the limbic white matter microstructure in aging and Alzheimer's Disease.

Anna S Lorenz, Aditi Sathe, Yisu Yang, Alaina Durant, Yiyang Wu, Michael E Kim, Chenyu Gao, Nancy R Newlin, Karthik Ramadass, Praitayini Kanakaraj and 38 more

Abstract read
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In one paragraph

Article in Alzheimer's & dementia : the journal of the Alzheimer's Association, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

48 authors.

Anna S LorenzVanderbilt Memory and Alzheimer's Center, Vanderbilt University School of Medicine, Nashville, Tennessee, USA.
Aditi SatheVanderbilt Memory and Alzheimer's Center, Vanderbilt University School of Medicine, Nashville, Tennessee, USA.
Yisu YangVanderbilt Memory and Alzheimer's Center, Vanderbilt University School of Medicine, Nashville, Tennessee, USA.
Alaina DurantVanderbilt Memory and Alzheimer's Center, Vanderbilt University School of Medicine, Nashville, Tennessee, USA.
Yiyang WuVanderbilt Memory and Alzheimer's Center, Vanderbilt University School of Medicine, Nashville, Tennessee, USA.
Michael E KimDepartment of Computer Science, Vanderbilt University, Nashville, Tennessee, USA.
Chenyu GaoDepartment of Electrical and Computer Engineering, Vanderbilt University, Nashville, Tennessee, USA.
Nancy R NewlinDepartment of Computer Science, Vanderbilt University, Nashville, Tennessee, USA.
Karthik RamadassDepartment of Computer Science, Vanderbilt University, Nashville, Tennessee, USA.
Praitayini KanakarajDepartment of Computer Science, Vanderbilt University, Nashville, Tennessee, USA.
Nazirah Mohd KhairiDepartment of Electrical and Computer Engineering, Vanderbilt University, Nashville, Tennessee, USA.
Zhiyuan LiDepartment of Electrical and Computer Engineering, Vanderbilt University, Nashville, Tennessee, USA.
Tianyuan YaoDepartment of Computer Science, Vanderbilt University, Nashville, Tennessee, USA.
Yuankai HuoDepartment of Electrical and Computer Engineering, Vanderbilt University, Nashville, Tennessee, USA.
Logan DumitrescuVanderbilt Memory and Alzheimer's Center, Vanderbilt University School of Medicine, Nashville, Tennessee, USA.
Niranjana ShashikumarVanderbilt Memory and Alzheimer's Center, Vanderbilt University School of Medicine, Nashville, Tennessee, USA.
Kimberly R PechmanVanderbilt Memory and Alzheimer's Center, Vanderbilt University School of Medicine, Nashville, Tennessee, USA.
Shannon L RisacherDepartment of Radiology and Imaging Sciences, Indiana University School of Medicine, Indianapolis, Indiana, USA.
Lori L Beason-HeldLaboratory for Behavioral Neuroscience, National Institute on Aging, National Institutes of Health, Baltimore, Maryland, USA.
Yang AnLaboratory for Behavioral Neuroscience, National Institute on Aging, National Institutes of Health, Baltimore, Maryland, USA.
Konstantinos ArfanakisDepartment of Biomedical Engineering, Illinois Institute of Technology, Chicago, Illinois, USA.
Guray ErusDepartment of Radiology, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Christos DavatzikosDepartment of Radiology, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Mohamad HabesNeuroimage Analytics Laboratory and Biggs Institute Neuroimaging Core, Glenn Biggs Institute for Alzheimer's and Neurodegenerative Diseases, University of Texas Health Science Center, San Antonio, Texas, USA.
Di WangNeuroimage Analytics Laboratory and Biggs Institute Neuroimaging Core, Glenn Biggs Institute for Alzheimer's and Neurodegenerative Diseases, University of Texas Health Science Center, San Antonio, Texas, USA.
Duygu TosunDepartment of Radiology and Biomedical Imaging, University of California, San Francisco, California, USA.
Arthur W TogaLaboratory of Neuroimaging, USC Stevens Institute of Neuroimaging and Informatics, Keck School of Medicine, University of Southern California, Los Angeles, California, USA.
Paul M ThompsonImaging Genetics Center, Mark and Mary Stevens Institute for Neuroimaging and Informatics, Keck School of Medicine, University of Southern California, Marina del Rey, California, USA.
Elizabeth C MorminoDepartment of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, California, USA.
Panpan ZhangVanderbilt Memory and Alzheimer's Center, Vanderbilt University School of Medicine, Nashville, Tennessee, USA.
Kurt SchillingDepartment of Radiology & Radiological Sciences, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Marilyn AlbertDepartment of Neurology, Johns Hopkins School of Medicine, Baltimore, Maryland, USA.
Walter KukullNational Alzheimer's Coordinating Center, University of Washington, Seattle, Washington, USA.
Sarah A BiberNational Alzheimer's Coordinating Center, University of Washington, Seattle, Washington, USA.
Bennett A LandmanVanderbilt Genetics Institute, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Sterling C JohnsonWisconsin Alzheimer's Disease Research Center, School of Medicine and Public Health, University of Wisconsin, Madison, Wisconsin, USA.
Barbara BendlinWisconsin Alzheimer's Disease Research Center, School of Medicine and Public Health, University of Wisconsin, Madison, Wisconsin, USA.
Julie SchneiderRush Alzheimer's Disease Center, Rush University Medical Center, Chicago, Illinois, USA.
David A BennettRush Alzheimer's Disease Center, Rush University Medical Center, Chicago, Illinois, USA.
Angela L JeffersonVanderbilt Memory and Alzheimer's Center, Vanderbilt University School of Medicine, Nashville, Tennessee, USA.
Susan M ResnickLaboratory for Behavioral Neuroscience, National Institute on Aging, National Institutes of Health, Baltimore, Maryland, USA.
Andrew J SaykinDepartment of Radiology and Imaging Sciences, Indiana University School of Medicine, Indianapolis, Indiana, USA.
Jennifer E BelowVanderbilt Memory and Alzheimer's Center, Vanderbilt University School of Medicine, Nashville, Tennessee, USA.
Timothy J HohmanVanderbilt Memory and Alzheimer's Center, Vanderbilt University School of Medicine, Nashville, Tennessee, USA.
Derek B ArcherVanderbilt Memory and Alzheimer's Center, Vanderbilt University School of Medicine, Nashville, Tennessee, USA.
Alzheimer's Disease Neuroimaging Initiative (ADNI)
BIOCARD Study Team (BIOCARD)
Alzheimer's Disease Sequencing Project (ADSP)

Funding

Alzheimer's Disease Neuroimaging Initiative - SupplementU01AG024904 · NIA · NORTHERN CALIFORNIA INSTITUTE RES &EDUC · PI WEINER, MICHAEL W · 2004 to 2015
$121.0M
Alzheimer's Association IIRG-08-88733American Heart Association 26PRE1558066NIH HHS 75N95D22P00141NIH HHS K01-AG073584NIH HHS K01-EB03289NIH HHS NIAAG021155NIH HHS NIAAG027161NIH HHS NIAAG037639NIH HHS NIAAG054047NIH HHS P30-AG066515NIH HHS R01-AG034962NIH HHS R01-AG056534NIH HHS R01-AG059716NIH HHS R01-AG074339NIH HHS R01-EB017230NIH HHS U01AG024904NIH HHS U19-AG03655NIH HHS U24-AG074855NIH HHS UL1-TR000445NIH HHS UL1-TR002243
6 · The paper itself

Abstract

introductionLimbic white matter (WM) abnormalities are prevalent in aging and Alzheimer's disease (AD), but genetic drivers are unclear.

methodsIn 2614 older adults (mean age ± SD: 73.7 ± 9.8 years; 26% cognitively impaired) from seven harmonized cohorts enriched for cognitive impairment, we quantified free-water-corrected diffusion MRI (dMRI) metrics in seven limbic tracts. We estimated single nucleotide polymorphism (SNP) heritability, performed cohort genome-wide association studies (GWASs) with meta-analysis, evaluated shared genetic architecture and enriched pathways, and assessed AD relevance using brain RNA-seq data.

resultsLimbic WM is heritable (h DISCUSSION: Limbic WM microstructure is genetically influenced and links oligodendrocyte and vascular-inflammatory biology to AD-relevant outcomes.

Indexed as

AgingAlzheimer DiseaseLimbic SystemWhite MatterAgedAged, 80 and overDiffusion Magnetic Resonance ImagingFemaleGenome-Wide Association StudyHumansMalePolymorphism, Single NucleotideagingAlzheimer's diseasediffusion MRIGWASharmonizationwhite matter microstructure

Identifiers

PMID42410730
PMCPMC13338108

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.