Evidence map›Paper›PMID 42410716›Full record

ArticleAlzheimer's & dementia : the journal of the Alzheimer's Association2026

Greater choroid plexus volume is linked to poor sleep, neurodegeneration, and cognitive deficits in older adults: Evidence from the IGNITE Study.

Miranda G Chappel-Farley, Kelsey R Sewell, Audrey M Collins, Cristina Molina-Hidalgo, Shivangi Jain, Haiqing Huang, Patricio Solis-Urra, Lauren E Oberlin, George Grove, Arthur F Kramer and 11 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Alzheimer's & dementia : the journal of the Alzheimer's Association, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors.

Miranda G Chappel-FarleyDepartment of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.ORCID https://orcid.org/0000-0003-1349-0507
Kelsey R SewellNeuroscience, AdventHealth Research Institute, Orlando, Florida, USA.
Audrey M CollinsNeuroscience, AdventHealth Research Institute, Orlando, Florida, USA.
Cristina Molina-HidalgoNeuroscience, AdventHealth Research Institute, Orlando, Florida, USA.
Shivangi JainNeuroscience, AdventHealth Research Institute, Orlando, Florida, USA.
Haiqing HuangNeuroscience, AdventHealth Research Institute, Orlando, Florida, USA.
Patricio Solis-UrraNeuroscience, AdventHealth Research Institute, Orlando, Florida, USA.
Lauren E OberlinNeuroscience, AdventHealth Research Institute, Orlando, Florida, USA.
George GroveDepartment of Psychology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Arthur F KramerBeckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign, Urbana, Illinois, USA.
Edward McAuleyBeckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign, Urbana, Illinois, USA.
Jeffrey M BurnsDepartment of Health and Kinesiology, University of Illinois at Urbana Champaign, Urbana, Illinois, USA.
Charles HillmanDepartment of Psychology, Northeastern University, Boston, Massachusetts, USA.
Eric D VidoniDepartment of Psychology, Northeastern University, Boston, Massachusetts, USA.
Bradley P SuttonBeckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign, Urbana, Illinois, USA.
Anna L MarslandDepartment of Psychology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
M Ilyas KambohDepartment of Human Genetics, University of Pittsburgh School of Public Health, Pittsburgh, Pennsylvania, USA.
Chaeryon KangDepartment of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.
Lu WanNeuroscience, AdventHealth Research Institute, Orlando, Florida, USA.
Kirk I EricksonNeuroscience, AdventHealth Research Institute, Orlando, Florida, USA.
Kristine A WilckensDepartment of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.

Funding

Investigating Gains in Neurocognition in an Intervention Trial of Exercise SupplementR01AG053952 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI BURNS, JEFFREY MURRAY, ERICKSON, KIRK I · 2016 to 2020
$27.5M
Translational Research Training in Sleep MedicineT32HL082610 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Daniel J. Buysse, PETER L FRANZEN · 2007 to 2026
$5.8M
Physical Activity and Dementia: Mechanisms of ActionR35AG072307 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI ERICKSON, KIRK I · 2021 to 2025
$3.6M
NHLBI NIH HHS T32HL082610NIA NIH HHS R01 AG053952NIA NIH HHS R35 AG072307
6 · The paper itself

Abstract

introductionPoor sleep is associated with neurodegenerative disease, but mechanisms are unclear. Greater volume of the choroid plexus (ChP), a brain structure supporting neurotoxic waste clearance, is linked to neurodegeneration and cognitive decline. We tested whether poor sleep promotes neurodegeneration and cognitive deficits via ChP dysfunction.

methodsBaseline magnetic resonance imaging (MRI) -derived ChP, hippocampal, ventricular, and gray matter volumes from 635 cognitively unimpaired older adults were analyzed. Sleep was measured with the Pittsburgh Sleep Quality Index and accelerometry. Confirmatory factor analysis generated cognitive domain scores.

resultsPoorer self-reported sleep quality was associated with greater ChP volume, while accelerometry measures were not. Greater ChP volume was associated with smaller hippocampi and gray matter, and larger ventricles. ChP mediated relationships between sleep quality and hippocampal and ventricular volumes. Gray matter mediated associations between ChP and cognitive domains. DISCUSSION: Altered ChP morphology may link poor sleep to neurodegeneration and cognitive decline in older adults.

Indexed as

Choroid PlexusCognitive DysfunctionNeurodegenerative DiseasesSleep Wake DisordersAccelerometryAgedAged, 80 and overFemaleGray MatterHippocampusHumansMagnetic Resonance ImagingMaleSleep Qualityaccelerometryagingchoroid plexuscognitionneurodegenerationolder adultssleep

Identifiers

PMID42410716
PMCPMC13337531

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.