ArticleBiological research2026
Expression and functional characterization of the TRPV3 channel in domestic cat (Felis catus) mature oocytes.
Article in Biological research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundIntracellular calcium (Ca
methodsOvaries from domestic cats were obtained during ovariohysterectomies, and oocytes were isolated and matured in vitro. Trpv3 expression was assessed by RT-PCR from ovaries and germinal vesicle (GV) and metaphase II (MII) oocytes, while TRPV3 localization was evaluated by immunocytochemistry. Mouse WT and TRPV3-knockout oocytes were used as controls for antibody specificity. Functional channel activity was examined using Ca
resultsWe detected Trpv3 transcripts in cat ovaries and in GV and MII oocytes. Immunocytochemistry confirmed TRPV3 protein localization at the oocyte membrane in cats, consistent with reports in mouse oocytes. Additionally, addition of 2-APB elicited robust intracellular increase in Ca
conclusionsOur results demonstrate functional TRPV3 expression in domestic cat oocytes. We find distinctive features in feline TRPV3 compared to rodent and human orthologs. These insights support the development of tailored artificial oocyte activation protocols in cats, with potential applications to Assisted Reproductive Technologies (ART) for endangered felids.
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