Evidence map›Paper›PMID 42410644›Full record

ReviewJournal of medical case reports2026

Hypereosinophilic syndrome mimicking gastric malignancy: considerations on the challenging diagnosis-a case report and review of the literature.

Yuzhi Liu, Hailin Yan, Qing Lu, Jinlin Yang

Abstract readCase ReportsReview
In one paragraph

Review in Journal of medical case reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Yuzhi Liu *Department of Gastroenterology and Hepatology, West China Hospital, Sichuan University, Guoxue Lane 37, the No. 1 Residential Building, Chengdu, 610041, Sichuan, China.ORCID http://orcid.org/0000-0001-7238-4224
Hailin Yan *Department of Gastroenterology and Hepatology, West China Hospital, Sichuan University, Guoxue Lane 37, the No. 1 Residential Building, Chengdu, 610041, Sichuan, China.ORCID http://orcid.org/0000-0003-0683-7947
Qing LuDepartment of Gastroenterology and Hepatology, West China Hospital, Sichuan University, Guoxue Lane 37, the No. 1 Residential Building, Chengdu, 610041, Sichuan, China.ORCID http://orcid.org/0000-0001-9107-1311
Jinlin YangDepartment of Gastroenterology and Hepatology, West China Hospital, Sichuan University, Guoxue Lane 37, the No. 1 Residential Building, Chengdu, 610041, Sichuan, China. mouse-577@163.com.ORCID http://orcid.org/0000-0001-8726-7258

Funding

Major technology application and demonstration project, Chengdu Science and Technology Bureau 2024-YF09-00016-SNNational Natural Science Foundation of China 82300755
6 · The paper itself

Abstract

backgroundHypereosinophilic syndromes (HES) are rare disorders characterized by the abnormal accumulation of eosinophils, which can lead to organ damage. The clinical manifestations are highly variable and can sometimes mimic tumors, presenting significant diagnostic challenges. This case report emphasizes the difficulty of diagnosing HES, particularly when it presents as a gastric pseudotumor, and the essential role of pathological examination in guiding diagnosis and treatment. CASE PRESENTATION: A 51-year-old Chinese Han female with a history of elevated eosinophils presented with epigastric pain, weight loss, and fatigue. Imaging suggested a gastric malignancy with possible metastasis. Despite these findings, biopsies revealed eosinophilic infiltration without malignancy. Based on persistent eosinophilia and multi-organ involvement, HES was diagnosed. The patient was treated with corticosteroids, resulting in significant clinical improvement, confirmed by follow-up imaging and endoscopic examination.

conclusionsThis case highlights the importance of distinguishing HES from malignancies to avoid unnecessary surgical interventions. Early recognition and appropriate corticosteroid treatment can lead to significant improvement, underscoring the importance of careful diagnostic evaluation in cases with ambiguous clinical presentations.

Indexed as

Hypereosinophilic SyndromeStomach NeoplasmsAbdominal PainAdrenal Cortex HormonesBiopsyDiagnosis, DifferentialFemaleHumansMiddle AgedTomography, X-Ray ComputedTreatment OutcomeAdrenal Cortex HormonesDiagnosisHypereosinophilic syndromesPathological examinationPseudotumorSteroid therapy

Identifiers

PMID42410644
PMCPMC13621753

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.