Evidence map›Paper›PMID 42410564›Full record

ArticleBMC medical education2026

Cost-effectiveness of virtual patient integration in dermatology education: evidence for precision education by learner expertise.

Chih-Tsung Hung, Sheng-Wen Liu, Shou-En Wu, Feng-Cheng Liu

Abstract read
In one paragraph

Article in BMC medical education, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Chih-Tsung HungDepartment of Dermatology, National Defense Medical University, Tri- Service General Hospital, Taipei, Taiwan.
Sheng-Wen LiuDepartment of Dermatology, National Defense Medical University, Tri- Service General Hospital, Taipei, Taiwan.
Shou-En WuDepartment of Dermatology, National Defense Medical University, Tri- Service General Hospital, Taipei, Taiwan.
Feng-Cheng LiuDivision of Rheumatology/Immunology and Allergy, Department of Internal Medicine, Tri-Service General Hospital, National Defense Medical University, No. 325, Section 2, Chenggong Road, Neihu District, Taipei, 11490, Taiwan. lfc10399@gmail.com.

Funding

Tri-Service General Hospital Research Program TSGH-E-114224 and TSGH-E-115231
6 · The paper itself

Abstract

backgroundEducational technology adoption accelerates despite limited evidence of incremental value within already-effective curricula. Pragmatic evaluations examining cost-effectiveness and differential benefits across learner populations with varying expertise remain scarce.

objectivesTo evaluate virtual patient integration into established flipped classroom curriculum, examining incremental educational outcomes, comprehensive cost-effectiveness, and systematic variation by training level.

methodsSequential implementation study at a tertiary teaching hospital in Taiwan (2022-2025). Flipped classroom (FC; 2022-2023, N = 131) was followed by FC with virtual patients (FC + VP; 2024-2025, N = 161). PRIMARY OUTCOMES: knowledge acquisition (Cohen's d, achievement rates ≥ 80%). Incremental cost-effectiveness ratios (ICERs) were calculated by training level.

resultsBoth approaches achieved extremely large learning effects (FC: d = 2.27; FC + VP: d = 2.43; >98% achievement; between-group differences non-significant). FC + VP required 3.08-fold higher per-student investment ($163 vs. $53). Cost-effectiveness varied dramatically: undergraduates showed meaningful gains (Δd = + 0.29, ICER = $383/d), while postgraduates showed minimal benefit (Δd = + 0.02, ICER = $4,670/d)-a 12.2-fold difference. Germane cognitive load was associated with learning progress (r = .196, R² = 8.5%); critical thinking was not independently associated (p = .497).

conclusionsNear-universal competency is attainable through multiple instructional approaches. Virtual patient integration was associated with differential incremental value by learner expertise-meaningful for novices but negligible for advanced learners achieving comparable outcomes more efficiently. Findings support precision education frameworks targeting technology investments based on cost-effectiveness profiles rather than universal deployment.

Indexed as

Education, Medical, UndergraduateClinical CompetenceCost-Benefit AnalysisCost-Effectiveness AnalysisCurriculumEducational MeasurementFemaleHumansMaleTaiwanCost-effectivenessExpertise reversalFlipped classroomMedical educationPrecision educationVirtual patients

Identifiers

PMID42410564
PMCPMC13625295

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.