Evidence map›Paper›PMID 42410520›Full record

ArticleBMC genomics2026

Identification of differentially expressed lncRNAs in different daily weight gains of Jiangquan black pigs and functional analysis of LOC100518120.

Jingsen Huang, Hongzhen Cao, Xinlin Jin, Qi Song, Wei Chen, Hui Tang, Yunzhou Wang, Yongqing Zeng

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PubMed Full text at PMC Publisher
In one paragraph

Article in BMC genomics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

8 authors.

Jingsen HuangShandong Provincial Key Laboratory for Livestock Germplasm Innovation & Utilization, College of Animal Science and Technology, Shandong Agricultural University, Tai'an, 271018, China.
Hongzhen CaoShandong Provincial Key Laboratory for Livestock Germplasm Innovation & Utilization, College of Animal Science and Technology, Shandong Agricultural University, Tai'an, 271018, China.
Xinlin JinShandong Provincial Key Laboratory for Livestock Germplasm Innovation & Utilization, College of Animal Science and Technology, Shandong Agricultural University, Tai'an, 271018, China.
Qi SongShandong Provincial Key Laboratory for Livestock Germplasm Innovation & Utilization, College of Animal Science and Technology, Shandong Agricultural University, Tai'an, 271018, China.
Wei ChenShandong Provincial Key Laboratory for Livestock Germplasm Innovation & Utilization, College of Animal Science and Technology, Shandong Agricultural University, Tai'an, 271018, China.
Hui TangShandong Provincial Key Laboratory for Livestock Germplasm Innovation & Utilization, College of Animal Science and Technology, Shandong Agricultural University, Tai'an, 271018, China.
Yunzhou WangDepartment of Veterinary Medicine, Shandong Vocational Animal Science and Veterinary College, Weifang, 261061, China.
Yongqing ZengShandong Provincial Key Laboratory for Livestock Germplasm Innovation & Utilization, College of Animal Science and Technology, Shandong Agricultural University, Tai'an, 271018, China. yqzeng@sdau.edu.cn.

Funding

Agricultural Animal Breeding Project of Shandong Province 2020LZGC012National Key R&D Program of China 2021YFD1301203Shandong Province pig Industry Technology System Project SDAIT-08-02
6 · The paper itself

Abstract

backgroundJiangquan black pig is a novel breed under development, characterized by rapid growth, high-quality meat, strong stress resistance, and high reproductive performance. However, the molecular mechanisms underpinning their muscle development remain poorly characterized. To address this gap, we conducted whole-transcriptome RNA-seq on longissimus dorsi muscle samples from Jiangquan black pigs with divergent growth rates (fast-growing vs. slow-growing) to identify key regulatory factors of muscle development.

resultsWe identified a total of 5,329 known and 331 novel lncRNAs from the transcriptomic data, among which 70 lncRNAs showed differential expression between the fast-growing and slow-growing groups. Functional enrichment analysis of these differentially expressed (DE) lncRNAs revealed that multiple DE-lncRNAs were associated with PPP3CB; three candidate lncRNAs (ENSSSCG00000036609, ENSSSCG00000047932, and the novel lncRNA LOC100518120) were further predicted as potential regulators of muscle growth. Subsequent functional validation in porcine skeletal muscle satellite cells confirmed that LOC100518120 significantly upregulates the expression of its downstream target gene G0S2, promotes cell proliferation and differentiation, and suppresses apoptosis.

conclusionsOur study identifies key lncRNA candidates associated with muscle growth in Jiangquan black pig, and elucidates the pro-myogenic functional role of the novel lncRNA LOC100518120. These findings provide a theoretical foundation for optimizing molecular breeding strategies and further improving meat quality in this breed.

Indexed as

Gene Expression ProfilingRNA, Long NoncodingAnimalsCell ProliferationMuscle DevelopmentMuscle, SkeletalSwineTranscriptomeRNA, Long NoncodingJiangquan black pigLongissimus dorsi muscleMuscle developmentRNA sequencing

Identifiers

PMID42410520
PMCPMC13617866

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