Evidence map›Paper›PMID 42409978›Full record

ArticleScientific reports2026

Integrated chemical and genomic analysis of lipopeptides produced by Bacillus velezensis CMRP4489 with antifungal activity.

Maria Luiza A Jesus-Nicoletto, Julia P Baptista, Sandriele A Noriler, Paula O Gouveia, Alicya M Bertoli, Daniel V Silva, Priscila G Camargo, Fernando Macedo, João P Oliveira, Ulisses P Pereira and 4 more

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Article in Scientific reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Maria Luiza A Jesus-NicolettoDepartment of Microbiology, State University of Londrina, Londrina, Brazil.
Julia P BaptistaDepartment of Microbiology, State University of Londrina, Londrina, Brazil.
Sandriele A NorilerDepartment of Microbiology, State University of Londrina, Londrina, Brazil.
Paula O GouveiaDepartment of Microbiology, State University of Londrina, Londrina, Brazil.
Alicya M BertoliDepartment of Microbiology, State University of Londrina, Londrina, Brazil.
Daniel V SilvaDepartment of Microbiology, State University of Londrina, Londrina, Brazil.
Priscila G CamargoDepartment of Chemistry, State University of Londrina, Londrina, Brazil.
Fernando MacedoDepartment of Chemistry, State University of Londrina, Londrina, Brazil.
João P OliveiraDepartment of Microbiology, State University of Londrina, Londrina, Brazil.
Ulisses P PereiraDepartment of Preventive Veterinary Medicine, State University of Londrina, Londrina, Brazil.
João C P MelloDepartment of Pharmacy, State University of Maringá, Maringá, Brazil.
Claudio R NovelloAcademic Department of Chemistry and Biology, Federal University of Technology of Paraná, Francisco Beltrão, PR, Brazil.
Ulisses RochaDepartment of Computational Biology and Chemistry, Helmholtz Centre for Environmental Research- UFZ GmbH, Leipzig, Germany. ulisses.rocha@ufz.de.ORCID 0000-0001-6972-6692
Admilton G de OliveiraDepartment of Microbiology, State University of Londrina, Londrina, Brazil. admilton@uel.br.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Biological control by microorganisms is an increasingly interesting alternative for reducing crop losses caused by phytopathogens. The strain Bacillus velezensis CMRP4489 (LABIM40) stands out for its strong biotechnological potential for controlling fungal phytopathogens, and, according to in silico analyses, 12 significant gene clusters in its genome encode secondary metabolite biosynthetic pathways. The present study aimed to produce, extract, identify, and evaluate in vitro and in silico the antifungal metabolites produced by B. velezensis CMRP4489 with activity against Sclerotinia sclerotiorum, a fungus responsible for white mold. The compound with the highest activity was identified by high-resolution electrospray ionization mass spectrometry (HR-ESI-MS) analyses and nuclear magnetic resonance (NMR) spectroscopy as bacillopeptin, a molecule of the iturin family. As a result, we included comparative genomics of the iturin family and related cyclic lipopeptides and found at least three biosynthetic gene clusters (BGCs) associated with these compounds. To our knowledge, the present study is the first to report the antifungal activity of bacillopeptins against S. sclerotiorum.

Indexed as

Antifungal AgentsAscomycotaBacillusLipopeptidesGenomicsMagnetic Resonance SpectroscopyMultigene FamilyPeptides, CyclicSpectrometry, Mass, Electrospray IonizationAntifungal AgentsLipopeptidesPeptides, CyclicAntifungal ActivityBacillus velezensis.Biological ControlBiosynthetic gene clustersMass spectrometrySclerotinia sclerotiorum

Identifiers

PMID42409978
PMCPMC13338125

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.