ArticleJournal of perinatology : official journal of the California Perinatal Association2026
Clinical effectiveness and safety of laser lancing for heel puncture in preterm infants: a randomized crossover non-inferiority trial.
Article in Journal of perinatology : official journal of the California Perinatal Association, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo evaluate the clinical effectiveness and safety of laser-lancing devices (LLDs) compared with an automatic incision device (AID) for heel puncture in preterm infants. STUDY
designA randomized crossover non-inferiority trial was conducted in 40 preterm infants between April and December 2021. Primary outcomes were procedural success rate, pain response assessed by the Premature Infant Pain Profile (PIPP), and skin penetration depth.
resultsLLD achieved a 75% first-attempt success rate, reaching 100% after a second attempt at a higher energy setting, whereas AID achieved 100% success on the first attempt. PIPP scores during the procedure were significantly lower with LLD than with AID (4.5 [3.0-6.0] vs. 6.5 [4.0-7.5]; P = 0.014). Penetration depths were similar between devices (1.21 ± 0.30 vs. 1.25 ± 0.23 mm).
conclusionsLLD appears to be non-inferior to AID in terms of effectiveness and safety for heel puncture in preterm infants, with reduced procedural pain. CLINICAL
trial registrationClinical Research Information Service (Registration No. KCT0010932).
Identifiers
42409970What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.